Related Experiment Video
Updated: Jul 26, 2025
07:23
Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities
Published on: July 29, 2014
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Activation of the Mu-Delta Opioid Receptor Heteromers Blocks Morphine Rewarding Effects
Ariadna Requana Aradas1, Youssra Djaboub1, Isabelle McCort-Tranchepain2
1Université Paris Cité, CNRS, Inserm, Pharmacologie et thérapies des addictions, Paris, France.
The International Journal of Neuropsychopharmacology
|June 21, 2023
Summary
Targeting mu opioid receptor (MOR)/delta opioid receptor (DOR) heteromers with CYM51010 shows promise for blocking morphine reward. This novel approach may reduce opioid side effects while maintaining therapeutic benefits.
Area of Science:
- Pharmacology
- Neuroscience
- Drug Addiction Research
Background:
- Opioid receptor heteromers, specifically mu opioid receptor (MOR)/delta opioid receptor (DOR) heteromers, are increasingly recognized.
- Targeting these heteromers offers a potential strategy to mitigate opioid side effects like tolerance and dependence.
- CYM51010, a MOR/DOR heteromer-preferring agonist, demonstrates antinociception comparable to morphine with reduced tolerance.
Purpose of the Study:
- To investigate the effects of CYM51010 on drug addiction-related behaviors in mice.
- To evaluate CYM51010's potential for blocking morphine-induced reward and dependence.
Main Methods:
- Assessment of CYM51010's effects on locomotor activity, psychomotor sensitization, and conditioned place preference in mice.
- Evaluation of CYM51010's impact on morphine-induced physical dependence and reinstatement of conditioned place preference.
Main Results:
- CYM51010 induced acute locomotor activity, psychomotor sensitization, and rewarding effects, similar to morphine.
- CYM51010 produced less physical dependence compared to morphine.
- CYM51010 blocked the reinstatement of extinguished morphine-induced conditioned place preference but not morphine-induced physical dependence.
Conclusions:
- Targeting MOR-DOR heteromers with agents like CYM51010 is a promising strategy for blocking morphine reward.
- This approach may offer a novel therapeutic avenue for managing opioid addiction and associated side effects.
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