Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

578
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
578

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Corneal deformation mapping and FE-based strain analysis via digital image correlation: Biomechanical changes after CXL and laser refractive surgery.

Experimental eye research·2026
Same author

Second-Generation ELZA-sub400 Protocol: Individualized High-Fluence Cross-Linking for Ultra-Thin Keratoconus Corneas.

American journal of ophthalmology·2026
Same author

Comment on "Impact of Simultaneous Topography-Guided PRK on Corneal Haze after Cross-Linking for Keratoconus: A Quantitative Densitometry Analysis".

Cornea·2026
Same author

Integration of Mechanical Testing, In Vivo Optical Coherence Elastography and Personalized Finite Element Modeling to Predict Geometrical Outcomes of Corneal Cross-Linking.

Annals of biomedical engineering·2026
Same author

[Anti-infectious cross-linking: when and how? : PACK-CXL as treatment option for infectious keratitis].

Die Ophthalmologie·2026
Same author

Stromal Transplantation and corneal-sparing techniques in ectatic diseases.

Progress in retinal and eye research·2026

Related Experiment Video

Updated: Jul 26, 2025

Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model
05:56

Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model

Published on: April 3, 2016

9.0K

Corneal crosslinking with riboflavin using sunlight.

Emilio A Torres-Netto1, Hormoz Abdshahzadeh, Nan-Ji Lu

  • 1From the Ocular Cell Biology Group, Center for Applied Biotechnology and Molecular Medicine, University of Zurich, Zurich, Switzerland (Torres-Netto, Abdshahzadeh, Abrishamchi, Hillen, F. Hafezi); ELZA Institute AG, Dietikon, Switzerland (Torres-Netto, Abdshahzadeh, Lu, Abrishamchi, Hillen, N. Hafezi, F. Hafezi); Department of Ophthalmology, Paulista School of Medicine, Federal University of Sao Paulo, Sao Paulo, Brazil (Torres-Netto); Faculty of Medicine, University of Geneva, Geneva, Switzerland (Torres-Netto, N. Hafezi, Koppen, F. Hafezi); Faculty of Medicine and Health Sciences, University of Antwerp, Wilrijk, Belgium (Lu, Koppen); Department of Ophthalmology, Antwerp University Hospital, Edegem, Belgium (Lu); Computer Vision Laboratory, Department of Information Technology and Electrical Engineering, Swiss Federal Institute of Technology, Zurich, Switzerland (Kling); Department of Ophthalmology, University of Southern California, Los Angeles, California (F. Hafezi); School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, Zhejiang, China (F. Hafezi).

Journal of Cataract and Refractive Surgery
|June 21, 2023
PubMed
Summary
This summary is machine-generated.

Sunlight exposure of riboflavin-soaked corneas increased stiffness, similar to corneal crosslinking (CXL). This suggests sunlight may offer a less invasive CXL alternative using oral riboflavin and fractioned light exposure.

More Related Videos

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis
07:29

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis

Published on: November 12, 2015

20.0K
Second Harmonic Generation Signals in Rabbit Sclera As a Tool for Evaluation of Therapeutic Tissue Cross-linking TXL for Myopia
12:25

Second Harmonic Generation Signals in Rabbit Sclera As a Tool for Evaluation of Therapeutic Tissue Cross-linking TXL for Myopia

Published on: January 6, 2018

7.8K

Related Experiment Videos

Last Updated: Jul 26, 2025

Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model
05:56

Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model

Published on: April 3, 2016

9.0K
Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis
07:29

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis

Published on: November 12, 2015

20.0K
Second Harmonic Generation Signals in Rabbit Sclera As a Tool for Evaluation of Therapeutic Tissue Cross-linking TXL for Myopia
12:25

Second Harmonic Generation Signals in Rabbit Sclera As a Tool for Evaluation of Therapeutic Tissue Cross-linking TXL for Myopia

Published on: January 6, 2018

7.8K

Area of Science:

  • Ophthalmology
  • Biotechnology
  • Biomaterials Science

Background:

  • Corneal crosslinking (CXL) is a standard procedure to stiffen corneas.
  • Current CXL methods utilize riboflavin and UV-A light.
  • Investigating alternative CXL methods is crucial for improving patient outcomes.

Purpose of the Study:

  • To determine if sunlight can induce biomechanical stiffening in riboflavin-soaked corneas.
  • To compare sunlight-induced stiffening with UV-A light-based CXL.

Main Methods:

  • Porcine eyes were used in an experimental study.
  • Riboflavin concentration in corneal stroma was measured.
  • De-epithelialized corneas were soaked in riboflavin (0.1% or 0.5%) and exposed to sunlight.
  • Elastic modulus was calculated to assess corneal stiffness.

Main Results:

  • Sunlight exposure significantly increased corneal stiffness in riboflavin-soaked corneas compared to controls.
  • Higher riboflavin concentration (0.5%) did not result in significantly greater stiffening than 0.1%.
  • A trend suggested longer UV-A exposure with 0.1% riboflavin might enhance stiffening.

Conclusions:

  • Sunlight exposure effectively stiffens riboflavin-soaked corneas.
  • This finding supports the potential of sunlight as a less invasive CXL technique.
  • Oral riboflavin and fractioned sunlight exposure may represent novel, less invasive CXL approaches.