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MORPHOLOGIC CHARACTERISTICS AND PROGRESSION PATTERNS OF MACULAR NEOVASCULARIZATION-RELATED ATROPHY IN EYES WITH

Shiqi Xie1, Hongshuang Lu, Changyu Chen

  • 1Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Tokyo, Japan.

Retina (Philadelphia, Pa.)
|June 21, 2023
PubMed
Abstract

Insights

Pathologic myopia can lead to three distinct patterns of macular neovascularization (MNV)-related atrophy. Some patterns impact vision significantly, while others spare the fovea, offering better visual recovery.

Area of Science:

  • Ophthalmology
  • Retinal Diseases
  • Myopia Research

Background:

  • Pathologic myopia is a leading cause of visual impairment.
  • Macular neovascularization (MNV) is a common complication in pathologic myopia.
  • Understanding MNV-related atrophy patterns is crucial for predicting visual outcomes.

Purpose of the Study:

  • To investigate the development and progression patterns of macular neovascularization (MNV)-related atrophies.
  • To analyze these patterns in eyes with pathologic myopia.

Main Methods:

  • A longitudinal study of 27 eyes from 26 patients with MNV followed from onset to atrophy.
  • Autofluorescence and optical coherence tomography imaging were used to identify atrophy patterns.
  • Best-corrected visual acuity changes were tracked over a 3-year follow-up.

Main Results:

  • Three distinct atrophy patterns were identified: multiple-atrophic (63%), single-atrophic (18.5%), and exudation-related (18.5%).
  • Multiple-atrophic and exudation-related patterns led to foveal involvement and decreased visual acuity.
  • The single-atrophic pattern spared the fovea, resulting in good visual recovery.

Conclusions:

  • There are three distinct patterns of MNV-related atrophy in pathologic myopia.
  • These patterns exhibit different progression courses and visual prognoses.
  • Identifying these patterns aids in predicting visual outcomes for patients with pathologic myopia.

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