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Updated: Jul 26, 2025

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing

Published on: June 1, 2012

Soft microfiber-based hollow microneedle array for stretchable microfluidic biosensing patch with negative

Mottour Vinayagam Chinnamani¹, Adeela Hanif¹, Padmanathan Karthick Kannan¹

¹School of Advanced Materials Science & Engineering, Sungkyunkwan University, Suwon, Gyeonggi-do, 16419, South Korea.

Biosensors & Bioelectronics

|June 21, 2023

Summary

This summary is machine-generated.

A new microneedle-integrated microfluidic biosensor patch (MIMBP) enables wearable, self-testing for personalized healthcare. This device accurately measures glucose in whole blood, paving the way for decentralized diagnostics.

Keywords:

Biosensor patch Blood glucose testing Hollow microfibers Hollow microneedle Microfluidics

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Polymeric Microneedle Array Fabrication by Photolithography

Polymeric Microneedle Array Fabrication by Photolithography

Published on: November 17, 2015

Area of Science:

Biomedical Engineering
Materials Science
Analytical Chemistry

Background:

Wearable point-of-care testing devices are crucial for personalized and decentralized healthcare.
Challenges exist in integrating conformable systems for biofluid sampling and precise biomolecule detection.
Existing systems often require complex operation protocols, limiting wearer convenience.

Purpose of the Study:

To develop a novel microneedle-integrated microfluidic biosensor patch (MIMBP) for seamless blood sampling and electrochemical biosensing.
To create a wearable system capable of accurate, minimally invasive biomolecule detection.
To advance personalized and decentralized healthcare through user-friendly diagnostic tools.

Main Methods:

Fabrication of a soft MIMBP using a stretchable microfluidic device, flexible electrochemical biosensor, and hollow microneedle (HMN) array.
HMNs were constructed from electroplated, durable hollow microfibers using a nanocomposite matrix.
Utilized negative pressure from a button push for blood collection and delivery to a biosensor modified with gold nanostructures and Pt nanoparticles.

Main Results:

Demonstrated accurate glucose measurement in whole human blood collected via the HMNs.
The MIMBP platform achieved high sensitivity for glucose detection.
The system proved effective for sequential blood collection and analysis.

Conclusions:

The proposed MIMBP platform with HMNs offers a promising foundation for future wearable, self-testing systems.
This technology facilitates minimally invasive biomolecule detection for personalized and decentralized healthcare.
The developed biosensor patch simplifies operation and enhances wearer convenience for continuous monitoring.