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An improved algorithm for design of broadband excitation, inversion, and mixing pulse sequences by iterative
Justin Jacob1, Tejas Shetty2, Navin Khaneja1
1Systems and Control Engineering Department, Indian Institute of Technology Bombay, Powai 400076, India.
Abstract:
This paper presents an improved iterative algorithm (TOPS-2) for the design of broadband inversion, excitation and coherent transfer mixing sequence (TOCSY) pulses. The evolution of the Bloch vector is presented as a sequence of small constant flip angle pulses with varying phases and constant amplitude. This paper describes an improved algorithm for iterative optimization of piece-wise constant phases as we incorporate the quadratic terms in the propagators. In our iterative optimization we obtain a closed-form expression for each phase, and these phases are optimized sequentially using the new improved algorithm. This paper compares the simulation results of the TOPS vs TOPS-2 and shows that TOPS-2 perform better. Experimental validation of excitation and inversion TOPS-2 pulse sequence is performed with .5% H2O in 99.5% D2O, and experimental validation of TOPS-2 mixing (TOCSY) pulse sequence is done with 0.1% of Ethylbenzene (EB) in CDCl3 solvent.
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