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Fever after cimetidine and ranitidine
Journal of Clinical Gastroenterology
|June 1, 1986
Summary
A multiple sclerosis patient developed fever and confusion after taking cimetidine and ranitidine. These symptoms suggest a potential adverse drug reaction to histamine H2 receptor antagonists in this patient population.
Area of Science:
- Neuroscience
- Clinical Pharmacology
Background:
- Multiple sclerosis (MS) is a chronic neurological disease.
- Histamine H2 receptor antagonists are commonly prescribed medications.
Observation:
- A 54-year-old bed-bound patient with multiple sclerosis presented with fever, mental confusion, and elevated creatinine levels.
- These symptoms emerged after initiating cimetidine and later ranitidine therapy.
Findings:
- The patient experienced a recurrence of fever and confusion upon a planned challenge with ranitidine.
- The exact mechanism, whether direct thermoregulatory center effect or hypersensitivity, remains undetermined.
Implications:
- This case highlights a potential association between histamine H2 receptor antagonists and adverse neurological and febrile reactions in multiple sclerosis patients.
- Further investigation is warranted to elucidate the safety profile of these drugs in neurological conditions.