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Related Experiment Videos

Fever after cimetidine and ranitidine.

H P Potter, E B Byrne, S Lebovitz

    Journal of Clinical Gastroenterology
    |June 1, 1986
    PubMed
    Summary

    A multiple sclerosis patient developed fever and confusion after taking cimetidine and ranitidine. These symptoms suggest a potential adverse drug reaction to histamine H2 receptor antagonists in this patient population.

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    Area of Science:

    • Neuroscience
    • Clinical Pharmacology

    Background:

    • Multiple sclerosis (MS) is a chronic neurological disease.
    • Histamine H2 receptor antagonists are commonly prescribed medications.

    Observation:

    • A 54-year-old bed-bound patient with multiple sclerosis presented with fever, mental confusion, and elevated creatinine levels.
    • These symptoms emerged after initiating cimetidine and later ranitidine therapy.

    Findings:

    • The patient experienced a recurrence of fever and confusion upon a planned challenge with ranitidine.
    • The exact mechanism, whether direct thermoregulatory center effect or hypersensitivity, remains undetermined.

    Implications:

    • This case highlights a potential association between histamine H2 receptor antagonists and adverse neurological and febrile reactions in multiple sclerosis patients.
    • Further investigation is warranted to elucidate the safety profile of these drugs in neurological conditions.

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