Heart Transplantation in Children and Adults With Congenital Heart Disease: 3 Decades of Evolution

Area of Science:

• Cardiology
• Pediatric Cardiology
• Transplantation Medicine

Background:

• Congenital heart disease (CHD) necessitates advanced treatments like heart transplantation.
• Heart transplantation is a critical intervention for pediatric and adult CHD patients.
• Single-center experiences provide valuable insights into transplantation outcomes.

Purpose of the Study:

• To report the single-center experience with heart transplantation.
• To analyze trends in heart transplantation over three decades.
• To evaluate long-term survival rates following heart transplantation in CHD patients.

Main Methods:

• Retrospective analysis of heart transplant data from a single center.
• Kaplan-Meier survival analysis was used to assess outcomes.
• Data were analyzed across three distinct decades of transplantation.

Main Results:

• The number of heart transplantations performed has increased over the last 30 years.
• Five-year survival rates for the first, second, and third decades were 69%, 62%, and 66%, respectively.
• Ten-year survival rates for the first, second, and third decades were 59%, 52%, and 60%, respectively.

Conclusions:

• Heart transplantation remains a vital treatment for congenital heart disease.
• While transplant volumes have risen, long-term survival rates show stability across recent decades.
• Continued monitoring and analysis of single-center data are essential for improving heart transplant outcomes.