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Updated: Jul 26, 2025

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
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Explainable AI via learning to optimize.

Howard Heaton1, Samy Wu Fung2

  • 1Typal Academy, Richland, USA. research@typal.academy.

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Summary
This summary is machine-generated.

This study introduces "learn to optimize" (L2O) for explainable artificial intelligence (XAI), offering transparent machine learning models that encode prior knowledge and provide verifiable trustworthiness. Applications include signal recovery and medical imaging.

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Area of Science:

  • Computer Science
  • Artificial Intelligence
  • Machine Learning

Background:

  • Machine learning models often function as "black boxes", hindering trust and adoption in critical applications.
  • There is a growing need for explainable artificial intelligence (XAI) that provides transparency and interpretability.
  • Encoding prior knowledge and flagging untrustworthy inferences are key challenges in current XAI.

Purpose of the Study:

  • To develop concrete tools for XAI that allow encoding of prior knowledge.
  • To propose methods for flagging untrustworthy inferences from machine learning models.
  • To enhance the transparency and interpretability of data-driven algorithms.

Main Methods:

  • Utilized the "learn to optimize" (L2O) methodology, framing inferences as data-driven optimization problems.
  • Implemented L2O models that directly incorporate prior knowledge and offer theoretical guarantees.
  • Introduced interpretable certificates for verifying the trustworthiness of model inferences.

Main Results:

  • L2O models demonstrated straightforward implementation and direct encoding of prior knowledge.
  • Theoretical guarantees, such as constraint satisfaction, were achieved.
  • Numerical examples in signal recovery, CT imaging, and cryptoasset trading validated the approach.

Conclusions:

  • The L2O methodology provides a practical framework for building explainable AI systems.
  • Interpretable certificates enhance the trustworthiness and verifiability of AI inferences.
  • This approach offers a promising direction for XAI in diverse scientific and financial domains.