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Related Experiment Video

Updated: Jul 26, 2025

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Signalling by senescent melanocytes hyperactivates hair growth.

Xiaojie Wang1,2,3, Raul Ramos4,5,6, Anne Q Phan7

  • 1Department of Developmental and Cell Biology, University of California, Irvine, CA, USA. xiaojiw2@uci.edu.

Nature
|June 21, 2023
PubMed
Summary

Senescent nevus melanocytes secrete osteopontin, driving hair stem cells to regenerate hair. This discovery highlights senescent cells as potential therapeutic targets for regenerative disorders.

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Area of Science:

  • Cell Biology
  • Dermatology
  • Regenerative Medicine

Background:

  • Niche signals regulate stem cell quiescence and activation for tissue regeneration.
  • Dysregulated niche signaling contributes to regenerative disorders.
  • Melanocytic nevi are associated with excessive hair growth, indicating hair stem cell hyperactivity.

Purpose of the Study:

  • To investigate the role of senescent melanocytes in nevus-associated hair growth.
  • To identify the molecular mechanisms by which nevus melanocytes influence hair stem cells.
  • To explore the therapeutic potential of targeting senescent cell signaling in regenerative disorders.

Main Methods:

  • Utilized genetic mouse models of nevi.
  • Analyzed the secretome of nevus melanocytes.
  • Investigated the role of osteopontin and its receptor CD44.
  • Examined human hairy nevi samples.

Main Results:

  • Senescent melanocytes in nevi induce hair stem cells to exit quiescence and enhance hair renewal.
  • Osteopontin is a key signaling factor secreted by nevus melanocytes, promoting hair growth.
  • Osteopontin and CD44 genetic deletion rescued enhanced hair growth.
  • Osteopontin is overexpressed in human hairy nevi and stimulates human hair follicle growth.

Conclusions:

  • Signaling from senescent cell clusters can enhance adjacent stem cell activity and stimulate tissue renewal.
  • Senescent melanocytes and their secretome, particularly osteopontin, are potent drivers of hair regeneration.
  • Senescent cells represent a promising therapeutic target for regenerative medicine.