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Updated: Jul 26, 2025

Non-Viral Engineering of Primary Human T Cells via Homology-Mediated End-Joining Targeted Integration of Large DNA Templates
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Non-Viral Engineering of Primary Human T Cells via Homology-Mediated End-Joining Targeted Integration of Large DNA Templates

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CLASH: large-scale engineering system for the discovery of better CAR T cells

Xiaoyun Dai1

  • 1Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. daixiaoyun@westlake.edu.cn.

Nature Reviews. Immunology
|June 21, 2023
PubMed
Abstract

No abstract available in PubMed .

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T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
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