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Association between SUMF1 polymorphisms and COVID-19 severity

Shaohui Liang¹, Huixia Gao², Tongxin He³

¹Department of Respiratory, Hebei Chest Hospital, Shijiazhuang, 050000, Hebei, China.

BMC Genomic Data

|June 21, 2023

Abstract

Background:

Evidence shows that genetic factors play important roles in the severity of coronavirus disease 2019 (COVID-19). Sulfatase modifying factor 1 (SUMF1) gene is involved in alveolar damage and systemic inflammatory response. Therefore, we speculate that it may play a key role in COVID-19.

Results:

We found that rs794185 was significantly associated with COVID-19 severity in Chinese population, under the additive model after adjusting for gender and age (for C allele = 0.62, 95% CI = 0.44-0.88, P = 0.0073, logistic regression). And this association was consistent with this in European population Genetics Of Mortality In Critical Care (GenOMICC: OR for C allele = 0.94, 95% CI = 0.90-0.98, P = 0.0037). Additionally, we also revealed a remarkable association between rs794185 and the prothrombin activity (PTA) in subjects (P = 0.015, Generalized Linear Model).

Conclusions:

In conclusion, our study for the first time identified that rs794185 in SUMF1 gene was associated with the severity of COVID-19.

Keywords:

COVID-19 Multiple sclerosis SUMF1 rs794185

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