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Heparin-resistance in AL amyloidosis: a case report
Elisabeth S van Ede1, Marlijn P A Hoeks2, Jan Hofland3
1Department of Intensive Care Medicine, Radboudumc, Nijmegen, the Netherlands.
BMC Anesthesiology
|June 21, 2023
Summary
Heparin resistance during cardiopulmonary bypass (CPB) can occur without antithrombin-III (AT-III) involvement. This case highlights the importance of understanding this rare resistance and considering direct thrombin inhibitors for anticoagulation.
Area of Science:
- Cardiovascular Surgery
- Hematology
- Anesthesiology
Background:
- Non-antithrombin-III (AT-III) mediated heparin resistance during cardiopulmonary bypass (CPB) arises from interactions with heparin-binding proteins.
- Current clinical guidelines lack specific recommendations for managing this type of heparin resistance.

