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Author Spotlight: Advancements in Molecular Biomarker Testing for Non-Squamous Non-Small Cell Lung Cancer

Author Spotlight: Advancements in Molecular Biomarker Testing for Non-Squamous Non-Small Cell Lung Cancer

Published on: September 8, 2023

Subtype-Based Microbial Analysis in Non-small Cell Lung Cancer.

Hye Jin Jang^1,2, Eunkyung Lee³, Young-Jae Cho⁴

¹Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.

Tuberculosis and Respiratory Diseases

|June 22, 2023

Summary

Lung cancer subtypes, adenocarcinoma and squamous cell carcinoma (SqCC), exhibit distinct microbiome profiles. SqCC showed lower microbiome diversity, suggesting its role in lung cancer development and prognosis.

Keywords:

Diversity Microbiome Non-small Cell Lung Cancer

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Published on: March 21, 2018

Area of Science:

Microbiology
Oncology
Pulmonology

Background:

The lung harbors a dynamic microbiome influencing respiratory health and disease.
Understanding lung microbiome composition is vital for managing lung diseases and optimizing treatments.
Histological differences in lung cancer may correlate with distinct microbiome profiles.

Purpose of the Study:

To investigate differences in lung cancer microbiomes based on histological subtypes.
To compare the lung microbiome between adenocarcinoma and squamous cell carcinoma (SqCC).

Main Methods:

16S rRNA sequencing was used to analyze the respiratory tract microbiome.
Bronchoalveolar lavage fluid was collected from lung cancer patients.
Patients were stratified into adenocarcinoma and SqCC groups.

Main Results:

Significant differences in alpha and beta diversity were observed between adenocarcinoma and SqCC groups.
Actinomyces graevenitzii was dominant in SqCC.
Adenocarcinoma showed higher abundance of Haemophilus parainfluenza, Neisseria subflava, Porphyromonas endodontalis, and Fusobacterium nucleatum.

Conclusions:

Lung microbiome diversity is critical for maintaining lung homeostasis; dysbiosis is linked to lung cancer development and prognosis.
Squamous cell carcinoma (SqCC) cases exhibited reduced microbiome diversity and higher mortality.
Further research is needed to elucidate the microbiome's role in different lung cancer types.