Comparison of HBV DNA and RNA markers in Alaska Native people who did and did not clear hepatitis B surface antigen

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Janet M Johnston1, Brian McMahon1, Brenna C Simons1

  • 1Liver Disease and Hepatitis Program, Alaska Native Tribal Health Consortium, Anchorage, Alaska, USA.

Journal of Viral Hepatitis
|June 22, 2023
PubMed

In a comparison between 50 Alaska Native persons with chronic hepatitis B who cleared HBV surface antigen (HBsAg) and 50 Alaska Native age-, sex-, and HBV genotype-matched controls, we found differences in changes in HBV DNA and HBV RNA levels over time but no difference in hepatitis B core-related antigen. These findings suggest that serial HBV DNA and HBV RNA may be associated with HBV functional cure defined by HBsAg clearance.

Keywords:
biomarkerschronic hepatitis Bhepatitis B Core antigenshepatitis B surface antigensseroconversion

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