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Related Experiment Video

Updated: Jul 26, 2025

A Micro-CT-based Method for Characterizing Lesions and Locating Electrodes in Small Animal Brains
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The Neurophysiological Lesion: A Scoping Review.

David N Taylor1

  • 1Department of Clinical Sciences, Texas Chiropractic College, Pasadena, Texas.

Journal of Chiropractic Medicine
|June 22, 2023
PubMed
Summary
This summary is machine-generated.

This review indicates that the central integrative state (CIS) of neurons can change with various disorders and treatments. Nonpharmacologic therapies, like spinal manipulation, may positively affect the neurophysiological lesion.

Keywords:
Central Nervous System SensitizationChiropracticManipulation, SpinalModels, NeurologicalNeuronal Plasticity

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Area of Science:

  • Neuroscience
  • Functional Neurology
  • Pain Research

Background:

  • The neurophysiological lesion is a concept in functional neurology.
  • Understanding changes in neuronal function is crucial for explaining various disorders and treatment effects.

Purpose of the Study:

  • To review the existing literature on the neurophysiological lesion within functional neurology.
  • To synthesize findings on central sensitization and related phenomena.

Main Methods:

  • A literature search was conducted from 2010 to March 2021.
  • Keywords included terms related to pain, sensitization, and neural inhibition.
  • Qualitative synthesis of 30 studies (7 high-level, 22 RCTs, 1 scoping review).

Main Results:

  • Evidence suggests changes in the central integrative state (CIS) of neurons in various disorders and with treatments.
  • The CIS demonstrates plasticity with pathologies and responds to conservative, nonpharmacologic treatments.

Conclusions:

  • The resting state of the CIS in the neurophysiological lesion may be altered by therapies, including manipulative therapy.
  • Nonpharmacologic care shows potential for affecting the neurophysiological lesion.
  • Further research is needed to target therapies to specific neuronal areas for distinct clinical outcomes.