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The Neurophysiological Lesion: A Scoping Review.

David N Taylor1

  • 1Department of Clinical Sciences, Texas Chiropractic College, Pasadena, Texas.

Journal of Chiropractic Medicine
|June 22, 2023
PubMed
Summary

This review indicates that the central integrative state (CIS) of neurons can change with various disorders and treatments. Nonpharmacologic therapies, like spinal manipulation, may positively affect the neurophysiological lesion.

Keywords:
Central Nervous System SensitizationChiropracticManipulation, SpinalModels, NeurologicalNeuronal Plasticity

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Area of Science:

  • Neuroscience
  • Functional Neurology
  • Pain Research

Background:

  • The neurophysiological lesion is a concept in functional neurology.
  • Understanding changes in neuronal function is crucial for explaining various disorders and treatment effects.

Purpose of the Study:

  • To review the existing literature on the neurophysiological lesion within functional neurology.
  • To synthesize findings on central sensitization and related phenomena.

Main Methods:

  • A literature search was conducted from 2010 to March 2021.
  • Keywords included terms related to pain, sensitization, and neural inhibition.
  • Qualitative synthesis of 30 studies (7 high-level, 22 RCTs, 1 scoping review).

Main Results:

  • Evidence suggests changes in the central integrative state (CIS) of neurons in various disorders and with treatments.
  • The CIS demonstrates plasticity with pathologies and responds to conservative, nonpharmacologic treatments.

Conclusions:

  • The resting state of the CIS in the neurophysiological lesion may be altered by therapies, including manipulative therapy.
  • Nonpharmacologic care shows potential for affecting the neurophysiological lesion.
  • Further research is needed to target therapies to specific neuronal areas for distinct clinical outcomes.