Jove
Visualize
Contact Us

Related Concept Videos

Autism Spectrum Disorder01:19

Autism Spectrum Disorder

163
Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
163
Intellectual Disability01:29

Intellectual Disability

120
Intellectual disability (ID) is a neurodevelopmental condition characterized by deficits in intellectual and adaptive functioning that manifest during the developmental period. This condition encompasses challenges in reasoning, memory, problem-solving, and learning, accompanied by impairments in everyday life skills, such as communication, self-care, and social interactions. Intellectual disability affects approximately 1% of the population in the United States, impacting an estimated 5...
120
Learning Disabilities01:25

Learning Disabilities

220
Learning disabilities are cognitive disorders caused by neurological impairments that affect cognitive functions like language and reading, without indicating overall intellectual or developmental challenges. These disabilities differ from global intellectual or developmental disabilities as they are limited to distinct cognitive functions. Common learning disabilities include dysgraphia, dyslexia, and dyscalculia, each of which impacts unique aspects of learning.
Dyslexia
Dyslexia is a...
220
Disorders of the Nervous Tissue01:28

Disorders of the Nervous Tissue

1.4K
Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
1.4K
Attention-Deficit/Hyperactivity Disorder01:30

Attention-Deficit/Hyperactivity Disorder

133
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
133
Three Developmental Domains01:29

Three Developmental Domains

191
Human development is typically examined across three main domains: physical, cognitive, and socio-emotional. These domains represent the significant areas of change and continuity throughout the lifespan, from infancy to late adulthood.
Physical Development
Physical processes, also known as maturation, encompass the biological changes that occur across an individual's life. These changes begin with genetic inheritance and continue through various stages, including growth in height and...
191

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Caregiver-Associated Physical Activity Patterns, Dietary Behaviors and Interventional Beliefs in Individuals with Down Syndrome: Insights from a Large European Survey.

Nutrients·2026
Same author

Understanding Obesity in Individuals with Down Syndrome: Caregiver Perceptions, Awareness, and Motivation.

Nutrients·2026
Same author

Promoting Research Excellence in Down Syndrome: Proceedings of the 5th International Conference of the Trisomy 21 Research Society.

Neuromolecular medicine·2026
Same author

Retrotransposons as both "architects" and "saboteurs" in the nervous system.

Advances in genetics·2026
Same author

Integrating Genetic Variants and Expression Profiles of Pharmacogenes to Investigate Resistance to Antidepressant Treatment.

Medicina (Kaunas, Lithuania)·2026
Same author

Common pathogenic mechanisms in the hippocampus across neurodegenerative dementias: Alzheimer's disease, Down syndrome, and Parkinson's disease.

NPJ dementia·2026
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jul 26, 2025

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells NPCs
10:47

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells NPCs

Published on: March 2, 2018

10.0K

Neurodevelopmental disorders: 2023 update.

Paulina Carriba1,2, Nicola Lorenzón1, Mara Dierssen1,3,2

  • 1Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain.

Free Neuropathology
|June 22, 2023
PubMed
Summary

Recent advances in neurodevelopmental diseases (NDDs) reveal new causes. Technologies like AI and organoids are uncovering mechanisms for conditions including autism spectrum disorder (ASD) and COVID-19 neurological effects.

Keywords:
CLIP: Caudal late interneuron progenitorCentrosomesHuman organoidsMCD: malformations of cortical developmentSUDC: sudden unexplained death in childhoodStress granules

More Related Videos

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
19:15

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

Published on: August 25, 2014

86.1K
Author Spotlight: A Lightweight Drive Implant for Chronic Tetrode Recordings in Juvenile Mice
06:34

Author Spotlight: A Lightweight Drive Implant for Chronic Tetrode Recordings in Juvenile Mice

Published on: June 2, 2023

2.9K

Related Experiment Videos

Last Updated: Jul 26, 2025

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells NPCs
10:47

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells NPCs

Published on: March 2, 2018

10.0K
Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
19:15

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

Published on: August 25, 2014

86.1K
Author Spotlight: A Lightweight Drive Implant for Chronic Tetrode Recordings in Juvenile Mice
06:34

Author Spotlight: A Lightweight Drive Implant for Chronic Tetrode Recordings in Juvenile Mice

Published on: June 2, 2023

2.9K

Area of Science:

  • Neuroscience
  • Genetics
  • Developmental Biology

Background:

  • Neurodevelopmental diseases (NDDs) are a diverse group of disorders with varied origins.
  • Technological advancements are crucial for understanding complex NDD aetiologies.

Purpose of the Study:

  • To highlight recent findings and proposed aetiological mechanisms for NDDs reported in 2022.
  • To showcase the impact of new technologies on NDD research.

Main Methods:

  • Proteomics and RNA-sequencing for molecular profiling.
  • Brain organoid models for studying neural development.
  • Artificial intelligence (AI) for biodata analysis.

Main Results:

  • Centrioles implicated in neuronal migration and periventricular heterotopia.
  • Misfolded protein accumulation linked to COVID-19 neurological effects.
  • Altered cortical arealization proposed as a mechanism for autism spectrum disorders (ASD).

Conclusions:

  • New insights into NDD aetiologies are emerging due to technological progress.
  • Specific findings include roles for centrioles, protein misfolding, and cortical development in NDDs.
  • Future research directions include studying stress granule deregulation, novel neural progenitors, and improved diagnostics for NDDs.