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Differences in structural parameters in patients with open-angle glaucoma, high myopia and both diseases
Agne Markeviciute1, Ingrida Januleviciene1, Gal Antman2,3
1Department of Ophthalmology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Plos One
|June 22, 2023
Summary
Patients with open-angle glaucoma and high myopia (OAG-M) showed the most significant thinning in retinal nerve fiber layer (RNFL) thickness and vessel density (VD). These findings may aid in diagnosing glaucoma in high myopia cases.
Area of Science:
- Ophthalmology
- Medical Imaging
- Glaucoma Research
Background:
- Open-angle glaucoma (OAG) and high myopia (M) are common ocular conditions.
- Concurrent OAG and M (OAG-M) may present unique structural changes.
- Understanding these differences is crucial for accurate diagnosis and management.
Purpose of the Study:
- To compare structural parameters between patients with OAG, M, and OAG-M.
- To identify specific markers indicative of OAG-M.
Main Methods:
- Prospective pilot study involving 42 subjects (14 each in OAG, M, and OAG-M groups).
- Evaluation of peripapillary retinal nerve fiber layer (RNFL) thickness and macular ganglion cell complex (GCC).
- Assessment of vessel density (VD) in the optic nerve head (ONH) and macula.
Main Results:
- The OAG-M group exhibited significantly lower mean peripapillary RNFL thickness and macular RNFL thickness.
- Lowest macular VD in the inferior quadrant was observed in the OAG-M group.
- The OAG-M group also showed the lowest ONH VD in the temporal quadrant.
Conclusions:
- The M group demonstrated the least thinning in peripapillary and macular RNFL.
- The M group had the highest macular and ONH vessel density.
- Specific structural decreases in the OAG-M group may assist in glaucoma diagnosis in high myopia.
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