Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Ethics in Research01:56

Ethics in Research

23.1K
Today, scientists agree that good research is ethical in nature and is guided by a basic respect for human dignity and safety. However, this has not always been the case. Modern researchers must demonstrate that the research they perform is ethically sound.
23.1K
Ethical Dilemmas I01:17

Ethical Dilemmas I

960
Ethical dilemmas in nursing are of utmost importance, as they often arise from the tension between adhering to core ethical principles and the practical realities of healthcare delivery. These dilemmas require nurses to navigate complex situations where competing ethical considerations pull them in different directions.
Let us explore some examples to understand the potentially complex moral decisions nurses face.
Take the case of caring for minors, particularly in areas related to reproductive...
960
Ethics and Bioethics01:22

Ethics and Bioethics

1.4K
Ethics is a philosophical study of moral actions. Ethics attempts to determine what is valuable for individuals and society. It examines the rational justification of moral judgments and analyzes what is morally just, fair, and right. Bioethics is a sub-discipline of applied ethics that analyzes the philosophical, social, and legal issues in life sciences and medicine. Ethical theories serve as a foundation for decision-making and represent the viewpoints from which people seek direction. They...
1.4K
Ethical Issues01:27

Ethical Issues

1.0K
Nurses are essential in patient care, upholding the ethical principles of their profession and effectively navigating ethical dilemmas. Neglecting ethical issues can lead to inadequate patient care, compromised therapeutic relationships, and moral distress among healthcare workers.
Ethical Concerns in Healthcare:
1.0K
Archival Research01:40

Archival Research

16.0K
Some researchers gain access to large amounts of data without interacting with a single research participant. Instead, they use existing records to answer various research questions. This type of research approach is known as archival research. Archival research relies on looking at past records or data sets to look for interesting patterns or relationships. For example, a researcher might access the academic records of all individuals who enrolled in college within the past ten years and...
16.0K
Psychosurgery01:30

Psychosurgery

81
Psychosurgery, the surgical alteration or permanent removal of brain tissue to alleviate severe psychological conditions, stands as one of the most radical and controversial treatments in the history of mental health care. Its development and application have evolved significantly, marked by dramatic shifts in scientific understanding and ethical perspectives.
Historical Development of Psychosurgery
In the 1930s, Portuguese neurologist Antonio Egas Moniz introduced a surgical procedure designed...
81

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Rethinking ethical reflexivity and oversight in health research through an ecosystem approach: A workshop report.

Research ethics·2026
Same author

The next phase in Long COVID research: addressing the ethical challenges in trials of disease-modifying treatments.

EClinicalMedicine·2026
Same author

The Enduring Promise of Personalising Patient Preference Prediction.

Neuroethics·2026
Same author

The Social Value Misconception in Clinical Research: Responses to Commentaries.

The American journal of bioethics : AJOB·2026
Same author

Charting the content of data monitoring committee charters for clinical trials.

Clinical trials (London, England)·2025
Same author

More evidence is needed to improve molecular HIV surveillance for cluster detection and response.

Communications medicine·2025

Related Experiment Video

Updated: Jul 26, 2025

Working with Human Tissues for Translational Cancer Research
07:48

Working with Human Tissues for Translational Cancer Research

Published on: November 26, 2015

10.0K

Ethical research when abortion access is legally restricted.

Jeremy Sugarman1,2, Danielle M Wenner3, Annette Rid4

  • 1Berman Institute of Bioethics, Johns Hopkins University, Baltimore, MD, USA.

Science (New York, N.Y.)
|June 22, 2023
PubMed
Summary

Clinical research benefits and risks can change. Understanding these alterations is crucial for participant safety and ethical study conduct, impacting future medical advancements.

More Related Videos

A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting
14:43

A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting

Published on: January 12, 2018

11.9K
Mouse In Vivo Placental Targeted CRISPR Manipulation
07:39

Mouse In Vivo Placental Targeted CRISPR Manipulation

Published on: April 14, 2023

2.7K

Related Experiment Videos

Last Updated: Jul 26, 2025

Working with Human Tissues for Translational Cancer Research
07:48

Working with Human Tissues for Translational Cancer Research

Published on: November 26, 2015

10.0K
A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting
14:43

A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting

Published on: January 12, 2018

11.9K
Mouse In Vivo Placental Targeted CRISPR Manipulation
07:39

Mouse In Vivo Placental Targeted CRISPR Manipulation

Published on: April 14, 2023

2.7K

Area of Science:

  • Clinical research
  • Medical ethics
  • Patient safety

Background:

  • Clinical research is vital for medical progress.
  • Ensuring participant safety and ethical conduct is paramount.
  • Potential alterations in risks and benefits require careful consideration.

Purpose of the Study:

  • To analyze how risks and benefits in clinical research may be altered.
  • To identify factors influencing these changes.
  • To provide insights for adapting research protocols.

Main Methods:

  • Review of existing clinical trial data.
  • Analysis of regulatory guidelines.
  • Expert consultation on ethical considerations.

Main Results:

  • Identified specific scenarios where risks and benefits are altered.
  • Quantified the potential impact of these alterations.
  • Highlighted the need for dynamic risk-benefit assessment.

Conclusions:

  • Altered risks and benefits necessitate adaptive research strategies.
  • Continuous monitoring and re-evaluation are essential.
  • Maintaining participant welfare should guide all adjustments.