Association between ambient air pollutants and lipid profile: A systematic review and meta-analysis

Studies of the effects of atmospheric pollutants on lipid profiles remain inconsistent and controversial.

The study was aimed to investigate the relationship between the exposure to ambient air pollutants and variations in the blood lipid profiles in the population.

A comprehensive search of three different databases (PubMed, Web of Science, and the Cochrane Library) until December 17, 2022, yielded 17 origional studies fulfilling the inclusion criteria for a meta-analysis. Aggregate effect measures and 95% confidence intervals (95% CI) for the relevant ambient air pollutants were deduced employing random effects models.

The collective meta-analysis indicated that long-term exposure to PM₁, PM_2.5, PM₁₀ and CO showed a substantial correlation with TC (PM₁: β = 2.04, 95%CI = 0.15-3.94; PM_2.5: β = 1.11, 95%CI = 0.39-1.84; PM₁₀: β = 1.70, 95%CI = 0.67-2.73; CO: β = 0.08, 95%CI = 0.06-0.10), PM₁₀ exhibited a significant association with TG (β = 0. 537,95% CI = 0.09-0.97), whereas HDL-C demonstrated notable relationships with PM₁, PM₁₀, SO₂ and CO (PM₁: β = -2.38, 95%CI = -4.00 to -2.76; PM₁₀: β = -0.77, 95%CI = -1.33 to -0.21; SO₂: β = -0.91, 95%CI = -1.73 to -0.10; CO: β = -0.03, 95%CI = -0.05 to 0.00). PM_2.5, PM₁₀ also showed significant associations with LDL-C (PM_2.5: β = 1.44 95%CI = 0.48-2.40; PM₁₀: β = 1.62 95%CI = 0.90-2.34). Subgroup analysis revealed significant or stronger correlations predominantly in cohort study designs, with higher male comparisons, and in regions exhibiting elevated contaminant levels.

In summary, the analysis substantiates that ambient air pollutants can be recognized as potent contributors to alterations in lipid profiles, particularly particulate pollutants which exert more obvious effects on lipid profiles.