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Dual-bioactive molecules loaded aligned core-shell microfibers for tendon tissue engineering.

Hongyun Xuan1, Zhuojun Zhang1, Wei Jiang1

  • 1School of Life Sciences, Nantong University, Nantong 226019, PR China.

Colloids and Surfaces. B, Biointerfaces
|June 22, 2023
PubMed
Summary
This summary is machine-generated.

This study developed an aligned fibrous scaffold using poly(L-lactic acid) (PLLA) with L-Arginine (Arg) and hyaluronic acid (HA) for enhanced tendon healing. The novel scaffold promotes cell activity and tendon regeneration, preventing adhesion.

Keywords:
Bioactive moleculesControlled delivery ultrafine fibrous systemTendon tissue engineering

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Tissue Engineering

Background:

  • Tendon healing requires advanced strategies for controlled bioactive molecule delivery.
  • Ultrafine fibrous systems offer promising platforms for tissue regeneration.

Purpose of the Study:

  • To develop an aligned ultrafine fibrous scaffold with sequential release of L-Arginine (Arg) and hyaluronic acid (HA) for tendon healing.
  • To investigate the efficacy of this novel scaffold in promoting tendon regeneration and preventing adhesion.

Main Methods:

  • Emulsion stable jet electrospinning was used to fabricate aligned poly(L-lactic acid) (PLLA) fibers incorporating Arg and HA.
  • The scaffold's structure, bioactive molecule release kinetics, and cellular responses (migration, proliferation) were analyzed.
  • An Achilles tendon repair model in rats was employed to evaluate in vivo efficacy.

Main Results:

  • The aligned Arg/HA/PLLA scaffold exhibited a core-shell structure enabling sequential release of Arg and HA.
  • Enhanced hydrophilicity, cell migration, spreading, and proliferation were observed.
  • The scaffold successfully prevented adhesion and promoted tendon regeneration in vivo.

Conclusions:

  • The developed Arg/HA/PLLA fibrous scaffold represents a novel biomimetic strategy for tendon regeneration.
  • Sequential release of bioactive molecules and enhanced cellular responses contribute to improved tendon healing.
  • This approach holds potential for creating advanced biofunctional scaffolds for musculoskeletal tissue repair.