Related Experiment Video
Updated: Jul 26, 2025

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging
Published on: March 14, 2025
Improving adherence to unguided Internet-based therapy for obsessive-compulsive disorder: A randomized controlled
Lena Jelinek1, Johanna Schröder2, Lara Bücker1
1Department of Psychotherapy and Psychiatry, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Internet-based cognitive-behavioral therapy (iCBT) for obsessive-compulsive disorder (OCD) shows effectiveness. A fixed module order may enhance OCD symptom reduction compared to a free-choice order, despite similar adherence.
Area of Science:
- Psychiatry and Behavioral Sciences
- Digital Health
- Clinical Psychology
Background:
- Low adherence to internet-based cognitive-behavioral therapy (iCBT) can limit its effectiveness for obsessive-compulsive disorder (OCD).
- Module autonomy (free choice vs. fixed order) is a potential factor influencing iCBT adherence and outcomes.
Purpose of the Study:
- To investigate if varying module autonomy in unguided iCBT impacts adherence and treatment effects for OCD.
- To compare the efficacy of a fixed module order (iCBTfixed) versus a free-choice module order (iCBTfree+) for OCD.
Main Methods:
- 151 individuals with OCD were randomized to iCBTfixed or iCBTfree+.
- Outcomes assessed at baseline, 8 weeks, and 16 weeks included OCD severity (Y-BOCS), adherence metrics, depression, self-esteem, and satisfaction.
- Intent-to-treat (ITT) and complete case (CC) analyses were performed.
Main Results:
- Both iCBT programs significantly reduced OCD severity.
- Complete case analyses indicated greater improvement in OCD severity and quality of life in the iCBTfixed group compared to iCBTfree+ from baseline to 8 weeks (medium effect sizes).
- No significant differences in adherence (utilization time, modules completed) were observed between the groups.
Conclusions:
- Unguided iCBT is effective for improving OCD symptoms.
- A fixed module order may offer superior treatment effects for OCD compared to a free-choice order, even with comparable adherence.
- Further research is needed to understand the relationship between adherence and outcomes in iCBT for OCD.
Related Concept Videos
Operant Conditioning Intervention
In operant conditioning, behaviors that are...
Obsessive-Compulsive Disorder
Treatment Strategies for Psychological Disorders
Psychological therapies focus on modifying emotions, thoughts, and behaviors through talking, interpreting, listening, rewarding, challenging, and modeling. Clinical psychologists, counselors, and social workers commonly practice psychotherapy. Clinical...
Blinding
Modeling in Therapy
Participant Modeling
Participant modeling involves therapists demonstrating calm and effective behaviors in...
Drug Therapy
Antianxiety Medications

