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Nanoparticle oral absorption and its clinical translational potential
Kyoung Sub Kim1, Kun Na2, You Han Bae3
1Department of Biotechnology, The Catholic University of Korea, 43 Jibong-ro, Wonmi-gu, Bucheon-si, Gyeonggi-do 14662, Republic of Korea.
Summary
Developing oral nanoparticles (NPs) faces challenges in delivering active pharmaceutical ingredients (APIs) effectively. This review highlights key parameters for improving the translational potential of oral NPs from preclinical models to human applications.
Area of Science:
- Pharmaceutical Sciences
- Nanotechnology
- Drug Delivery
Background:
- Oral drug administration is preferred but challenging for poorly soluble, large, or unstable active pharmaceutical ingredients (APIs).
- Nanoparticles (NPs) have been developed to enhance oral bioavailability via various uptake pathways.
- Preclinical findings often fail to translate to human efficacy due to species differences and physiological variability.
Conclusions:
- Careful selection of design parameters is crucial for successful oral nanoparticle development.
- Addressing translational challenges requires a deeper understanding of species-specific and patient-specific factors.
- Future research should focus on optimizing NP design for reliable oral delivery in humans.
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