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Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
Published on: September 27, 2024
306
Sex-specific differences in colorectal cancer: A multicenter retrospective cohort study
Hyun Jin Joo1, Hyun Seok Lee2, Byung Ik Jang3
1Division of Gastroenterology, Department of Internal Medicine, Chung-Ang University Medical Center, Seoul, Republic of Korea.
Cancer Reports (Hoboken, N.J.)
|June 22, 2023
Summary
This study found no significant differences in colorectal cancer (CRC) survival between men and women in Korea. However, men were more often diagnosed with rectal cancer, while women had more right colon cancer.
Area of Science:
- Oncology
- Sex-based Medicine
- Gastroenterology
Background:
- Colorectal cancer (CRC) exhibits sex-specific differences in incidence and characteristics.
- Understanding these differences is crucial for developing targeted screening, treatment, and prevention strategies.
- Few studies have investigated sex-specific CRC differences in the Republic of Korea.
Purpose of the Study:
- To assess and compare sex differences in colorectal cancer (CRC) within the Republic of Korea.
- To identify potential disparities in CRC presentation, characteristics, and outcomes between males and females.
- To inform the development of sex-tailored approaches for CRC management.
Main Methods:
- Retrospective, multicenter cohort study of 3,114 CRC patients diagnosed between 2012-2013.
- Exclusion of patients with uncertain staging, prior/concurrent cancers, or non-epithelial/in situ cancers.
- Analysis of survival outcomes (overall and progression-free) using Cox regression, Kaplan-Meier, and log-rank tests; comparison of demographic and clinical factors using chi-square, Fisher's exact, or t-tests.
Main Results:
- No significant age-at-onset difference between sexes; men more frequently diagnosed via health check-ups and asymptomatic (48.9% vs 42.0%).
- Rectal cancer more prevalent in men (38.8% vs 31.8%), while right colon cancer more common in women (31.4% vs 22.7%).
- KRAS mutations observed in 34.4% of women vs 23.3% of men; overall and progression-free survival were similar between sexes.
Conclusions:
- Sex differences in colorectal cancer (CRC) presentation and tumor location exist in the Korean population.
- Biological and socio-behavioral factors likely contribute to observed sex disparities.
- Considering sex-specific factors in CRC screening, diagnosis, and treatment is essential for improving patient outcomes.
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