Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Glomerular Filtration Rate and its Regulation01:28

Glomerular Filtration Rate and its Regulation

3.0K
The Glomerular Filtration Rate (GFR) is a measure of kidney function, reflecting the volume of filtrate formed per minute in the kidneys. On average, GFR is approximately 125 mL/min in males and 105 mL/min in females. Maintaining a relatively constant GFR is essential for the kidneys to effectively regulate body fluid homeostasis and maintain extracellular stability.
GFR regulation involves two primary intrinsic controls: the myogenic and tubuloglomerular feedback mechanisms.
The myogenic...
3.0K
Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

10
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
10
Renal Corpuscle01:20

Renal Corpuscle

2.9K
The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
2.9K
Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

37
Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
37
Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

41
Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
41
Inflammatory Response01:28

Inflammatory Response

2.2K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
2.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Challenges in the diagnosis, classification and prognosis of ANCA-associated vasculitis.

Nature reviews. Rheumatology·2025
Same author

Low dose IL-2 administration prevents but fails to treat experimental autoimmune anti-myeloperoxidase glomerulonephritis.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association·2025
Same author

Burden of Infection-Related Hospitalization and the Impact of Multidisciplinary Care in ANCA-Associated Vasculitis: A Retrospective Cohort.

International journal of rheumatic diseases·2025
Same author

Relationships between patient and physician global assessments in anti-neutrophil cytoplasmic antibody-associated vasculitis.

Clinical rheumatology·2024
Same author

Neutralizing the IL-7Rα limits injury in experimental ANCA-associated glomerulonephritis.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association·2024
Same author

The implication of anti-Ro60 with or without anti-Ro52 antibody in patients with systemic lupus erythematosus.

Rheumatology (Oxford, England)·2024
Same journal

KDIGO Life Cycle of Guideline Development Series Part 6: Bridging the Gap between Guidelines and Clinical Practice: The KDIGO Approach to Global Implementation and Education in Nephrology.

Kidney international·2026
Same journal

KDIGO Life Cycle of Guideline Development Series Part 5: Guideline updates and a living model for the future.

Kidney international·2026
Same journal

Crystal-storing histiocytosis causing severe acute kidney injury.

Kidney international·2026
Same journal

Peritoneal dialysis in a patient with extensive burn scarring.

Kidney international·2026
Same journal

COPA syndrome unmasked by anti-neutrophil cytoplasmic antibody-positive immune-complex nephritis.

Kidney international·2026
Same journal

Monitoring anti-nephrin antibodies in the management of recurrent diffuse podocytopathy.

Kidney international·2026
See all related articles

Related Experiment Video

Updated: Jul 26, 2025

Detection of MicroRNA Expression in the Kidneys of Immunoglobulin A Nephropathic Mice
05:39

Detection of MicroRNA Expression in the Kidneys of Immunoglobulin A Nephropathic Mice

Published on: July 8, 2020

1.9K

RORing toward immunoregulation in glomerulonephritis?

Chunni Lu1, A Richard Kitching2

  • 1Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, Monash University, Clayton, Victoria, Australia.

Kidney International
|June 22, 2023
PubMed
Summary
This summary is machine-generated.

Regulatory T cells expressing forkhead box protein 3 and retinoid acid-related orphan receptor γt are prominent in experimental glomerulonephritis and human vasculitis. These cells regulate immune responses within the kidney.

More Related Videos

Isolation of Double Negative αβ T Cells from the Kidney
06:56

Isolation of Double Negative αβ T Cells from the Kidney

Published on: May 16, 2014

12.4K
Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
09:43

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

3.0K

Related Experiment Videos

Last Updated: Jul 26, 2025

Detection of MicroRNA Expression in the Kidneys of Immunoglobulin A Nephropathic Mice
05:39

Detection of MicroRNA Expression in the Kidneys of Immunoglobulin A Nephropathic Mice

Published on: July 8, 2020

1.9K
Isolation of Double Negative αβ T Cells from the Kidney
06:56

Isolation of Double Negative αβ T Cells from the Kidney

Published on: May 16, 2014

12.4K
Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
09:43

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

3.0K

Area of Science:

  • Immunology
  • Cellular Biology
  • Renal Medicine

Background:

  • Forkhead box protein 3 (FOXP3)-expressing regulatory T cells are crucial for immune tolerance.
  • Retinoid acid-related orphan receptor γt (RORγt) is typically associated with T-helper 17 (Th17) cells.
  • The role of FOXP3+RORγt+ regulatory T cells in kidney inflammation is not well understood.

Purpose of the Study:

  • To investigate the presence and function of FOXP3+RORγt+ regulatory T cells in a model of glomerulonephritis.
  • To determine if these cells are present in human kidney diseases.

Main Methods:

  • Utilized a mouse model of rapidly progressive glomerulonephritis.
  • Analyzed kidney and spleen tissues from experimental models.
  • Examined kidney biopsies from patients with anti-neutrophil cytoplasmic antibody-associated vasculitis.

Main Results:

  • FOXP3+RORγt+ regulatory T cells were found to be abundant in experimental glomerulonephritis, both locally and systemically.
  • These cells were also identified in the kidneys of patients with anti-neutrophil cytoplasmic antibody-associated vasculitis.
  • Despite RORγt expression, these cells demonstrated regulatory functions on cellular immunity within the kidney.

Conclusions:

  • FOXP3+RORγt+ regulatory T cells are a significant component of the immune infiltrate in experimental glomerulonephritis.
  • These cells are present in human kidney diseases, suggesting a conserved role.
  • These regulatory T cells play a functional role in modulating immune responses in kidney inflammation.