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Updated: Jul 26, 2025

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

Microstructural changes precede depression in patients with relapsing-remitting Multiple Sclerosis.

Frank Riemer^1,2, Ellen Skorve^3,4, Ofer Pasternak^5,6

¹Mohn Medical Imaging and Visualization Centre (MMIV), Department of Radiology, Haukeland University Hospital, 5021, Bergen, Norway. f.riemer@web.de.

Communications Medicine

|June 22, 2023

Summary

This summary is machine-generated.

Early brain changes in Multiple Sclerosis (MS) are linked to later depression. Higher free water in subcortical MS lesions predicts depression symptoms, highlighting a key relationship.

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Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla

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Area of Science:

Neuroimaging
Neurology
Psychiatry

Background:

Multiple Sclerosis (MS) brain lesions can cause cognitive and mood disturbances.
Early microstructural changes in subcortical volumes may precede emotional dysfunction in MS patients.

Purpose of the Study:

To investigate the temporal relationship between early subcortical microstructural changes and cognitive/emotional function in relapsing-remitting MS.
To explore how early MRI-derived metrics predict later mood states in MS.

Main Methods:

Longitudinal in vivo MRI (3 years) in 46 relapsing-remitting MS patients.
Assessed subcortical microstructural changes using free water fraction (FW-MRI).
Correlated FW-MRI metrics with Hospital Anxiety and Depression Scale scores using predictive modeling.

Main Results:

Baseline free water estimates in subcortical structures correlated with depression scores at 2-year follow-up.
Thalamus FW-MRI showed the largest effect size in predicting depression.
Significant FW-MRI differences observed in thalamus and amygdala/hippocampus between high and low depression groups.

Conclusions:

Elevated free water in early-stage MS subcortical structures is associated with later depression symptoms.
This finding suggests FW-MRI can identify individuals at risk for depression in MS.