Related Experiment Video
Updated: Jul 26, 2025
07:32
Human Ex vivo Wound Model and Whole-Mount Staining Approach to Accurately Evaluate Skin Repair
Published on: February 17, 2021
7.4K
Skin microbiome attributes associate with biophysical skin ageing
Wei Zhou1, Elizabeth Fleming1, Guylaine Legendre2
1The Jackson Laboratory, Farmington, Connecticut, USA.
Experimental Dermatology
|June 23, 2023
Summary
Skin ageing involves biophysical changes and microbiome shifts. This study links collagen diffusion to specific bacterial strains and antibiotic resistance genes, revealing key interactions during ageing.
Area of Science:
- Dermatology
- Microbiology
- Biophysics
Background:
- Skin ageing results from biophysical changes and microbiome alterations.
- Understanding the interplay between these factors is crucial for anti-ageing strategies.
Purpose of the Study:
- To investigate the detailed interactions between skin's biophysical properties and its microbiome during ageing.
- To identify specific microbial species, strains, and genes associated with age-related skin changes.
Main Methods:
- Utilized shotgun metagenomics for high-resolution analysis of the skin microbiome.
- Controlled for confounding factors to isolate interactions between skin biophysics and microbiome.
- Measured key skin biophysical traits, including the collagen diffusion coefficient.
Main Results:
- Established significant associations between skin biophysical traits and skin microbiome composition.
- Found correlations between the collagen diffusion coefficient and the abundance of specific bacterial strains, including those from nosocomial infections.
- Identified links between skin biophysics and the prevalence of antibiotic resistance genes in the skin microbiome.
Conclusions:
- Skin biophysical features are closely associated with age-related alterations in the skin microbiome.
- Findings provide testable hypotheses for the mechanisms driving these interactions.
- Highlights potential targets for interventions in skin ageing.
More Related Videos
Related Concept Videos
01:19The Effect of Aging on Tissues
2.2K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.2K
01:12Renewal of Skin Epidermal Stem Cells
2.6K
The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
2.6K
01:23Skin Diseases and Disorders
3.9K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
3.9K
01:23Anatomy of the Intestines
72.6K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
72.6K
01:26Aging
89
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
89
01:21Accessory Structures of the Skin: Sebaceous Glands
2.0K
A sebaceous gland is a type of oil gland found almost all over the skin ( except palms and soles) and helps lubricate and waterproof the skin and hair. Most sebaceous glands are associated with hair follicles. They generate and excrete sebum, a mixture of lipids, onto the skin surface, thereby naturally lubricating the dry and dead layer of keratinized cells of the stratum corneum, keeping it pliable.
These glands that produce the oils on the skin and hair are holocrine glands. The mature...
These glands that produce the oils on the skin and hair are holocrine glands. The mature...
2.0K