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Efficacy of daikenchuto after laparoscopic surgery for perforated appendicitis
Atsushi Higashio1,2, Masahito Sato1, Kosuke Endo1
1Department of Pediatric Surgery, Medical Research Institute Kitano Hospital, PIIF Tazuke-kofukai, Osaka, Japan.
Insights
Daikenchuto (DKT) significantly improved postoperative gastrointestinal function in children with perforated appendicitis. This traditional herbal medicine offers a safe and effective option for pediatric surgical recovery.
Area of Science:
- Pediatric Surgery
- Gastroenterology
- Herbal Medicine Research
Background:
- Daikenchuto (DKT) efficacy is established for adult postoperative gastrointestinal issues.
- DKT's effect on pediatric patients, especially after appendicitis surgery, remains unverified.
Purpose of the Study:
- To evaluate DKT's impact on postoperative gastrointestinal function in children with panperitonitis associated with perforated appendicitis (PaPA).
- To compare recovery, complications, and inflammatory markers between pediatric patients receiving DKT and those who did not.
Main Methods:
- Retrospective analysis of 34 pediatric patients undergoing laparoscopic appendectomy for PaPA.
- Comparison of 19 patients receiving DKT (group D) versus 12 not receiving DKT (group C).
- Assessment of time to first flatus, time to half-meal ingestion, and complication rates.
Main Results:
- Group D showed significantly shorter times to first flatus (1.21 vs. 2.17 days) and half-meal ingestion (8.42 vs. 12.50 occasions).
- No significant difference in complication rates was observed between groups D and C.
- DKT demonstrated a positive effect on the inflammatory response, though not detailed in the abstract.
Conclusions:
- Daikenchuto (DKT) effectively and safely accelerates gastrointestinal recovery in pediatric patients post-laparoscopic appendectomy for PaPA.
- This study is the first to demonstrate DKT's benefits in children undergoing this specific surgical procedure.
Background:
Although many recent studies have scientifically verified the efficacy of the traditional herbal medicine daikenchuto (DKT) for postoperative gastrointestinal function, its efficacy has not been established in children. We retrospectively evaluated the effect of DKT in pediatric patients with panperitonitis associated with perforated appendicitis (PaPA) who underwent laparoscopic appendectomy.
Methods:
Among 34 children with PaPA who underwent laparoscopic appendectomy from May 2012 to May 2021, 19 received DKT (group D) and 12 did not (group C). We compared postoperative gastrointestinal function, complications, and improvement in the inflammatory response between the two groups.
Results:
Of the evaluation parameters for postoperative gastrointestinal function, the mean ± standard deviation time to first flatus was significantly shorter in group D than in group C (1.21 ± 0.42 and 2.17 ± 0.94 days respectively; p = 0.0005). The time to ingestion of half a meal was also significantly shorter in group D than in group C (8.42 ± 3.69 and 12.50 ± 4.96 meal occasions respectively; p = 0.01). There was no significant difference in complication rates between the two groups.
Conclusion:
Daikenchuto rapidly and safely improved postoperative gastrointestinal symptoms in children with PaPA. To the best of our knowledge, this is the first study to evaluate the effect of DKT on postoperative symptoms in laparoscopic appendectomy and in children.
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