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Arterial stiffness is associated with cancer mortality: Insight from Kailuan study

Jiatian Li1, Tesfaldet Habtemariam Hidru1, Yajuan Lin1

  • 1Department of Cardiology, Institute of Cardiovascular Diseases, First Affiliated Hospital of Dalian Medical University, Dalian, China.

Cancer Medicine
|June 23, 2023
PubMed

Insights

Increased arterial stiffness, measured by brachial-ankle pulse wave velocity (baPWV), is linked to a higher risk of all-cause mortality in cancer patients (ACMC). This risk is particularly pronounced in men and younger cancer patients.

Area of Science:

  • Cardiovascular Health
  • Oncology
  • Vascular Biology

Background:

  • Limited evidence exists on the link between arterial stenosis and all-cause mortality in cancer patients (ACMC).
  • Arterial stiffness, assessed via brachial-ankle pulse wave velocity (baPWV), is a marker of vascular health.
  • This study aimed to explore the association between baPWV and ACMC.

Purpose of the Study:

  • To investigate the relationship between arterial stiffness, measured by baPWV, and the risk of all-cause mortality in cancer patients.
  • To determine if arterial function and structure, as indicated by baPWV, predict mortality in individuals with cancer.

Main Methods:

  • A cohort of 43,943 Chinese adults underwent baPWV examinations.
  • Cox proportional hazards models were employed to analyze the association between baPWV values and ACMC.
  • Follow-up duration averaged 3.81 ± 2.50 years, with 157 deaths recorded among 553 cancer cases.

Main Results:

  • Patients with baPWV ≥18 m/s exhibited an elevated risk of ACMC compared to those with ideal vascular function.
  • A significant association was found between arterial stiffness severity and ACMC (HR 2.72; p < 0.001) for baPWV ≥18 m/s.
  • Each 1-SD increase in baPWV correlated with increased ACMC risk (HR 1.20; p < 0.05) in the overall cohort, men, and patients ≤60 years.

Conclusions:

  • Elevated arterial stiffness, indicated by higher baPWV, is significantly associated with an increased risk of all-cause mortality in cancer patients.
  • The heightened risk of ACMC associated with high baPWV (≥18 m/s) was particularly evident in men and individuals aged 60 years or younger.
  • These findings suggest that baPWV may serve as a valuable prognostic marker for mortality risk in cancer patients.
Abstract

Keywords:
arterial stiffnesscancermalignancymortality

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