Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Opioid Analgesics: Synthetic and Semisynthetic Opioids01:15

Opioid Analgesics: Synthetic and Semisynthetic Opioids

347
Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
347
Endoscopic Procedures IV: Sigmoidoscopy and Laproscopy01:26

Endoscopic Procedures IV: Sigmoidoscopy and Laproscopy

126
Sigmoidoscopy and laparoscopy are distinct medical procedures that enable physicians to internally inspect different parts of the GI tract. Although they serve different purposes, each is essential for diagnosing and, in some cases, treating various medical conditions.
Sigmoidoscopy
Sigmoidoscopy is a diagnostic procedure that uses a flexible sigmoidoscope equipped with a light source and camera to examine the rectum and sigmoid colon. The procedure involves inserting the tube through the anus...
126
Opioid Analgesics: Morphine and Other Natural Cogeners01:20

Opioid Analgesics: Morphine and Other Natural Cogeners

301
Opioids are a class of drugs that mimic endogenous opioid peptides and act on opioid receptors, and help in pain relief. These compounds are classified as natural, synthetic, or semi-synthetic. Natural opioids, like morphine, codeine, and thebaine, are derived from the opium poppy plant (Papaver somniferum or Papaver album) and are termed opiates. Synthetic opioids are artificial, while semi-synthetic opioids combine natural and synthetic compounds. Morphine, a prototypical opioid, possesses a...
301
Parenteral Anesthetics: Overview01:24

Parenteral Anesthetics: Overview

160
Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.
160
Cardiomyopathy VII: Pre and Post Operative Nursing Management01:28

Cardiomyopathy VII: Pre and Post Operative Nursing Management

16
Patients with hypertrophic cardiomyopathy (HCM) and left ventricular outflow tract (LVOT) obstruction who remain symptomatic despite optimal medical therapy may undergo a septal myectomy (Morrow procedure). This procedure involves excising a portion of the hypertrophied septum below the aortic valve using a heart-lung machine to improve blood flow through the LVOT. Effective preoperative and postoperative nursing management ensures successful patient outcomes, minimizes complications, and...
16
Local Anesthetics: Clinical Application as Epidural Anesthesia01:29

Local Anesthetics: Clinical Application as Epidural Anesthesia

460
Epidural anesthetics are administered in the fat-filled epidural space, the outermost part of the spinal canal. This technique is commonly employed for pain management and anesthesia during lower abdomen and pelvis surgeries or labor and delivery.
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
460

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Manual versus Automatic Perioperative QTc Interval Assessment: A Prospective Observational Investigation.

Anesthesia and analgesia·2026
Same author

Single-dose intraoperative methadone and QTc interval: a prospective observational cohort investigation.

British journal of anaesthesia·2026
Same author

Publication integrity and industry influences on the editorial process: a case study.

Research integrity and peer review·2026
Same author

White paper: robotic cholecystectomy-new technology but safe principles still apply.

Surgical endoscopy·2026
Same author

Adrenal lesions in young adults: variability in radiology reporting and implications for clinical evaluation.

Abdominal radiology (New York)·2026
Same author

Corrigendum to 'Morphine and hydromorphone pharmacodynamics in human volunteers: population-based modelling of interindividual response variability and utility' (Br J Anaesth 2026; 136: 1459-71).

British journal of anaesthesia·2026

Related Experiment Video

Updated: Jul 26, 2025

Less-Invasive Technique for Non-stabilized Mandibular Fracture in Mouse Models
04:13

Less-Invasive Technique for Non-stabilized Mandibular Fracture in Mouse Models

Published on: September 27, 2024

391

Intraoperative Methadone in Next-day Discharge Outpatient Surgery: A Randomized, Double-blinded, Dose-finding Pilot

Evan D Kharasch1, L Michael Brunt2, Jane Blood3

  • 1Department of Anesthesiology, Duke University, Durham, North Carolina.

Anesthesiology
|June 23, 2023
PubMed
Summary
This summary is machine-generated.

Single-dose intraoperative methadone effectively reduced pain and opioid use in patients undergoing outpatient surgery for next-day discharge. This approach proved feasible and well-tolerated, offering a promising alternative to traditional opioid regimens.

More Related Videos

Combining Laser Capture Microdissection and Microfluidic qPCR to Analyze Transcriptional Profiles of Single Cells: A Systems Biology Approach to Opioid Dependence
09:54

Combining Laser Capture Microdissection and Microfluidic qPCR to Analyze Transcriptional Profiles of Single Cells: A Systems Biology Approach to Opioid Dependence

Published on: March 8, 2020

5.3K
A Novel Surgical Technique As a Foundation for In Vivo Partial Liver Engineering in Rat
13:27

A Novel Surgical Technique As a Foundation for In Vivo Partial Liver Engineering in Rat

Published on: October 6, 2018

8.1K

Related Experiment Videos

Last Updated: Jul 26, 2025

Less-Invasive Technique for Non-stabilized Mandibular Fracture in Mouse Models
04:13

Less-Invasive Technique for Non-stabilized Mandibular Fracture in Mouse Models

Published on: September 27, 2024

391
Combining Laser Capture Microdissection and Microfluidic qPCR to Analyze Transcriptional Profiles of Single Cells: A Systems Biology Approach to Opioid Dependence
09:54

Combining Laser Capture Microdissection and Microfluidic qPCR to Analyze Transcriptional Profiles of Single Cells: A Systems Biology Approach to Opioid Dependence

Published on: March 8, 2020

5.3K
A Novel Surgical Technique As a Foundation for In Vivo Partial Liver Engineering in Rat
13:27

A Novel Surgical Technique As a Foundation for In Vivo Partial Liver Engineering in Rat

Published on: October 6, 2018

8.1K

Area of Science:

  • Anesthesiology
  • Pharmacology
  • Pain Management

Background:

  • Perioperative care aims to minimize intraoperative opioid use, reduce postoperative pain, and limit post-discharge opioid prescriptions.
  • Intraoperative methadone has shown promise in inpatient settings for reducing pain and opioid consumption.
  • This study investigates methadone's feasibility for outpatient same-day surgery discharge.

Purpose of the Study:

  • To assess the feasibility of a single intraoperative methadone dose for outpatient surgery with next-day discharge.
  • To determine an optimal, well-tolerated, and analgesic dose of methadone.
  • To compare postoperative opioid use with methadone versus conventional short-acting opioids.

Main Methods:

  • A double-blind, randomized, dose-escalation pilot study.
  • Compared single-dose IV methadone (0.1-0.3 mg/kg ideal body weight) against short-acting opioid controls.
  • Assessed perioperative opioid use, pain, and side effects, with 30-day follow-up via patient diaries.

Main Results:

  • The optimal dose was determined to be 0.25 mg/kg ideal body weight (median 14 mg).
  • In-hospital opioid use was significantly lower in the methadone groups (20-27 mg MME) compared to controls (46 mg MME).
  • No significant difference in opioid-related side effects was observed; home pain and opioid use were numerically lower with methadone.

Conclusions:

  • Single-dose intraoperative methadone at 0.25 mg/kg ideal body weight is feasible, analgesic, and opioid-sparing for outpatient surgery with next-day discharge.
  • Methadone demonstrates potential for reducing overall opioid burden in ambulatory surgical settings.
  • This pilot study supports further investigation into methadone as a component of multimodal analgesia in outpatient surgery.