Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Assessment of Cerebrospinal Fluid and Blood-Based Biomarkers in Degenerative Cervical Myelopathy: Systematic Review and Meta-Analysis.

Global spine journal·2025
Same author

Complex forelimb movements and cortical topography evoked by intracortical microstimulation in male and female mice.

Cerebral cortex (New York, N.Y. : 1991)·2022
Same author

Chronic inactivation of the contralesional hindlimb motor cortex after thoracic spinal cord hemisection impedes locomotor recovery in the rat.

Experimental neurology·2021
Same author

Development and plasticity of complex movement representations.

Journal of neurophysiology·2021
Same author

Sex differences in the effect of the FKBP5 inhibitor SAFit2 on anxiety and stress-induced reinstatement following cocaine self-administration.

Neurobiology of stress·2020
Same author

Seizures Alter Cortical Representations for Complex Movements.

Neuroscience·2020

Related Experiment Video

Updated: Jul 26, 2025

The Mouse Stroke Unit Protocol with Standardized Neurological Scoring for Translational Mouse Stroke Studies
10:45

The Mouse Stroke Unit Protocol with Standardized Neurological Scoring for Translational Mouse Stroke Studies

Published on: February 7, 2025

712

Extensive complex neocortical movement topography devolves to simple output following experimental stroke in mice.

Cassandra C Wolsh1, Rogers Milton Brown1, Andrew R Brown1

  • 1Department of Cellular and Integrative Physiology, Joe R. and Teresa Lozano Long School of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States.

Frontiers in Systems Neuroscience
|June 23, 2023
PubMed
Summary

Stroke injury alters the brain

Keywords:
complex movementintracortical microstimulationmiddle cerebral artery strokemotor cortexmotor outputneocortex

More Related Videos

Modeling Stroke in Mice: Focal Cortical Lesions by Photothrombosis
06:07

Modeling Stroke in Mice: Focal Cortical Lesions by Photothrombosis

Published on: May 6, 2021

6.4K
Compensatory Limb Use and Behavioral Assessment of Motor Skill Learning Following Sensorimotor Cortex Injury in a Mouse Model of Ischemic Stroke
08:01

Compensatory Limb Use and Behavioral Assessment of Motor Skill Learning Following Sensorimotor Cortex Injury in a Mouse Model of Ischemic Stroke

Published on: July 10, 2014

11.5K

Related Experiment Videos

Last Updated: Jul 26, 2025

The Mouse Stroke Unit Protocol with Standardized Neurological Scoring for Translational Mouse Stroke Studies
10:45

The Mouse Stroke Unit Protocol with Standardized Neurological Scoring for Translational Mouse Stroke Studies

Published on: February 7, 2025

712
Modeling Stroke in Mice: Focal Cortical Lesions by Photothrombosis
06:07

Modeling Stroke in Mice: Focal Cortical Lesions by Photothrombosis

Published on: May 6, 2021

6.4K
Compensatory Limb Use and Behavioral Assessment of Motor Skill Learning Following Sensorimotor Cortex Injury in a Mouse Model of Ischemic Stroke
08:01

Compensatory Limb Use and Behavioral Assessment of Motor Skill Learning Following Sensorimotor Cortex Injury in a Mouse Model of Ischemic Stroke

Published on: July 10, 2014

11.5K

Area of Science:

  • Neuroscience
  • Motor control
  • Stroke research

Background:

  • The neocortex is crucial for motor output in mammals.
  • Neocortical reorganization after stroke influences motor recovery.
  • Understanding these changes is vital for optimizing clinical care.

Purpose of the Study:

  • To investigate alterations in neocortical motor output topography post-stroke.
  • To correlate these changes with motor function recovery in mice.

Main Methods:

  • Middle cerebral artery occlusion (MCAo) model in mice.
  • Long-duration intracortical microstimulation (LD-ICMS) to map motor outputs.
  • Single pellet reaching (SPR) task to assess forelimb motor function.

Main Results:

  • MCAo injury altered neocortical motor maps 6 weeks post-stroke.
  • Reduced area for complex movements, increased area for simple movements.
  • Motor recovery correlated positively with the area of specific motor outputs.

Conclusions:

  • Stroke significantly reorganizes the neocortical motor map.
  • Specific changes in motor map area relate to functional recovery.
  • Findings inform strategies for stroke rehabilitation and neuroplasticity research.