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Amyloids and protein aggregation

Sara Linse¹, Tuomas Knowles²

¹Lund University, Biochemistry & Structural Biology Chemical Centre Lund Sweden sara.linse@biochemistry.lu.se.

Chemical Science

|June 23, 2023

Abstract:

A general discovery in protein science in the past few decades has been the finding that a number of unrelated proteins and peptides all have a marked propensity to form amyloid fibrils in vivo and in vitro. These structures have become known as the pathological hallmark of some of the most prevalent neurodegenerative diseases. More recently, the process of amyloid formation has been demystified through a number of key mechanistic findings, some of which are highlighted in this themed collection.

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