Related Experiment Video

Updated: Jul 25, 2025

A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis
10:26

A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis

Published on: June 2, 2015

17.3K

Early diagnostic value of intima-media thickness and D-dimer levels for vascular dementia

Haiping Xia1, Biao Jin1, Cen Su1

  • 1Zhenjiang 4th People's Hospital Affiliated to Jiangsu University, Jiangsu, China.

Medicine
|June 23, 2023
PubMed

Insights

Combining D-dimer and Doppler Intima-Media Thickness (IMT) significantly improves early vascular dementia (VaD) diagnosis. This combined approach offers higher sensitivity and specificity than individual tests for detecting this cognitive decline.

Area of Science:

  • Neurology
  • Vascular Medicine
  • Diagnostic Imaging

Background:

  • Vascular dementia (VaD) poses a significant diagnostic challenge, particularly in its early stages.
  • Current diagnostic methods may lack sufficient sensitivity for early detection, impacting timely intervention.
  • Cerebrovascular disease markers are crucial for understanding VaD pathogenesis.

Purpose of the Study:

  • To assess the diagnostic efficacy of combining D-dimer levels and Doppler Intima-Media Thickness (IMT) for early vascular dementia (VaD) detection.
  • To compare the diagnostic performance of the combined D-dimer and IMT approach against individual markers.
  • To explore the utility of these markers in evaluating the severity of cognitive decline in VaD patients.

Main Methods:

  • A cohort study involving 100 initial VaD patients and 100 healthy controls.
  • Collection and analysis of clinical data, including medical history and laboratory test results.
  • Measurement of D-dimer levels and Doppler assessment of Intima-Media Thickness (IMT).

Main Results:

  • Both D-dimer and IMT were found to be significantly elevated in patients with initial VaD.
  • The combined diagnostic approach demonstrated a sensitivity of 90.2% and a specificity of 87.9% (AUC=0.872).
  • The combined D-dimer and IMT test outperformed individual measurements in diagnosing early VaD.

Conclusions:

  • Combined D-dimer and IMT testing offers superior diagnostic value for early vascular dementia compared to single markers.
  • These markers are significantly increased during the initial onset of cerebrovascular diseases, aiding early diagnosis.
  • The combined detection is recommended for screening, routine examination, and prognosis evaluation in VaD, potentially assessing cognitive decline severity.

More Related Videos

Using Retinal Imaging to Study Dementia09:17

Using Retinal Imaging to Study Dementia

Published on: November 6, 2017

21.7K
A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology09:33

A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology

Published on: February 7, 2015

16.4K

Related Concept Videos

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies01:20

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
16
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
19
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
16
Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
42