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Researching COVID to Enhance Recovery (RECOVER) adult study protocol: Rationale, objectives, and design
Leora I Horwitz1, Tanayott Thaweethai2, Shari B Brosnahan3
1Department of Population Health, NYU Grossman School of Medicine, New York, New York, United States of America.
Plos One
|June 23, 2023
Summary
The RECOVER-Adult study investigates long COVID (post-acute sequelae of SARS-CoV-2 infection) in adults. It aims to define PASC prevalence, characteristics, risk factors, and biological mechanisms to improve understanding and treatment.
Area of Science:
- Epidemiology
- Infectious Diseases
- Public Health
Background:
- Post-acute sequelae of SARS-CoV-2 infection (PASC), or long COVID, presents ongoing or new symptoms after acute infection.
- The characteristics, prevalence, trajectory, and mechanisms of PASC remain poorly understood.
- Understanding PASC is crucial for developing effective public health strategies and clinical interventions.
Purpose of the Study:
- To characterize PASC prevalence and identify distinct phenotypes.
- To determine demographic, social, and clinical risk factors for PASC onset and recovery.
- To elucidate the biological mechanisms underlying PASC pathogenesis.
Main Methods:
- A large-scale, combined prospective/retrospective cohort study (RECOVER-Adult) enrolling 14,880 adults.
- Quarterly questionnaires, biospecimen collection, and physical/laboratory examinations over time.
- Advanced statistical methods, including machine learning, to define and analyze PASC cases and risk factors.
Main Results:
- The study is designed to provide the first national, prospective, longitudinal data on PASC in US adults.
- Analysis will focus on PASC onset, symptomology, and resolution.
- Identification of risk factors and biological underpinnings of PASC.
Conclusions:
- This study will establish a comprehensive understanding of PASC in the US adult population.
- Findings will inform public health policy, guide clinical trial design, and support the development of novel treatments for long COVID.
- The RECOVER-Adult study represents a significant step towards mitigating the long-term health impact of SARS-CoV-2 infection.
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