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Relationship between the systemic immune-inflammatory index and the severity of acute bronchiolitis in children

Ömer Furkan Kızılsoy1, Muhammet Furkan Korkmaz1, Gülsüm Elif Şenkan1

  • 1Department of Pediatrics, University of Health Sciences, Bursa Faculty of Medicine, City Training and Research Hospital, Bursa, Turkey.

Laboratory Medicine
|June 23, 2023
PubMed

Insights

The systemic immune-inflammatory index (SII) can help assess the severity of acute bronchiolitis (AB) in children. Higher SII values were observed in severe AB cases, suggesting its utility as a biomarker for disease stratification.

Area of Science:

  • Pediatrics
  • Immunology
  • Respiratory Medicine

Background:

  • Acute bronchiolitis (AB) is a common childhood respiratory illness with global health implications.
  • The systemic immune-inflammatory index (SII) is emerging as a potential biomarker for inflammation.
  • Assessing AB severity is crucial for effective patient management.

Purpose of the Study:

  • To investigate the utility of SII in assessing the severity of acute bronchiolitis in pediatric patients.
  • To evaluate SII as a potential new-generation inflammatory biomarker for AB severity stratification.

Main Methods:

  • A prospective observational study included 74 pediatric patients diagnosed with AB.
  • Patients were categorized into mild, moderate, and severe AB groups based on a modified Tal score.
  • Complete blood count, C-reactive protein, procalcitonin, and SII were analyzed. Receiver operating characteristic (ROC) analysis was used to assess predictive performance.

Main Results:

  • Neutrophil count, neutrophil-to-lymphocyte ratio, and SII were significantly elevated with increasing AB severity.
  • Red cell distribution width was higher in the moderate AB group.
  • SII demonstrated the highest area under the curve in ROC analysis for differentiating severe AB cases.

Conclusions:

  • Pediatric patients hospitalized with AB exhibited significantly higher SII values in the severe disease group.
  • SII may serve as a valuable tool for additional severity stratification in children with acute bronchiolitis.
Abstract

Keywords:
acute bronchiolitischildseveritysystemic immune-inflammatory index

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