Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inflammatory Response01:28

Inflammatory Response

2.2K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
2.2K
Inflammatory Response I: Vascular and Cellular01:30

Inflammatory Response I: Vascular and Cellular

11.5K
The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
11.5K
Inflammation01:38

Inflammation

54.0K
Overview
54.0K
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

2.9K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
2.9K
Phagocytosis of Apoptotic Cells01:17

Phagocytosis of Apoptotic Cells

3.9K
Cells undergoing apoptosis form apoptotic bodies that must be removed immediately to prevent inflammation, autoimmune diseases, and necrosis. Phagocytosis is carried out by professional phagocytes such as macrophages or  immature dendritic cells. Non-professional phagocytes such as  epithelial cells and fibroblasts also take part in this process; however, they are not as effective as professional phagocytes. 
Normal cells contain receptors that prevent them from being recognized...
3.9K
Necrosis01:16

Necrosis

4.6K
Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become...
4.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Advancements in extracellular vesicle research.

Extracellular vesicle·2026
Same author

Structural basis and regulation of GSDME pore formation.

Nature communications·2026
Same author

Redefining Shiga toxin-induced human cell death as NLRP1- and gasdermin E-mediated pyroptosis.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

LPS-induced structural reorganization and polymerization drive noncanonical inflammasome activation.

Science advances·2026
Same author

RNA N-glycosylation enables immune evasion and homeostatic efferocytosis.

Nature·2025
Same author

Endolysosomal damage surveillance enables rapid inflammasome sensing of pathogens.

Cell reports·2025

Related Experiment Video

Updated: Jul 25, 2025

Author Spotlight: THP-1 Macrophage Response to LPS/ATP — Unveiling the Pyroptosis, Apoptosis, and Necroptosis Spectrum
06:12

Author Spotlight: THP-1 Macrophage Response to LPS/ATP — Unveiling the Pyroptosis, Apoptosis, and Necroptosis Spectrum

Published on: May 3, 2024

2.1K

Pyroptosis-induced inflammation and tissue damage.

Swathy O Vasudevan1, Bharat Behl2, Vijay A Rathinam1

  • 1Department of Immunology, UConn Health School of Medicine, 263 Farmington Ave, Farmington, CT 06030, USA.

Seminars in Immunology
|June 23, 2023
PubMed
Summary

Pyroptosis, a programmed cell death, is triggered by gasdermin proteins. While crucial for immunity, excessive pyroptosis causes harmful inflammation and tissue damage in diseases.

Keywords:
Caspase-1GSDMDInflammationLPSPyroptosisSepsis

More Related Videos

Evaluation of Caspase Activation to Assess Innate Immune Cell Death
10:23

Evaluation of Caspase Activation to Assess Innate Immune Cell Death

Published on: January 20, 2023

3.3K
Detection of Inflammasome Activation and Pyroptotic Cell Death in Murine Bone Marrow-derived Macrophages
06:52

Detection of Inflammasome Activation and Pyroptotic Cell Death in Murine Bone Marrow-derived Macrophages

Published on: May 21, 2018

10.8K

Related Experiment Videos

Last Updated: Jul 25, 2025

Author Spotlight: THP-1 Macrophage Response to LPS/ATP — Unveiling the Pyroptosis, Apoptosis, and Necroptosis Spectrum
06:12

Author Spotlight: THP-1 Macrophage Response to LPS/ATP — Unveiling the Pyroptosis, Apoptosis, and Necroptosis Spectrum

Published on: May 3, 2024

2.1K
Evaluation of Caspase Activation to Assess Innate Immune Cell Death
10:23

Evaluation of Caspase Activation to Assess Innate Immune Cell Death

Published on: January 20, 2023

3.3K
Detection of Inflammasome Activation and Pyroptotic Cell Death in Murine Bone Marrow-derived Macrophages
06:52

Detection of Inflammasome Activation and Pyroptotic Cell Death in Murine Bone Marrow-derived Macrophages

Published on: May 21, 2018

10.8K

Area of Science:

  • Cell Biology
  • Immunology
  • Pathology

Background:

  • Pyroptosis is a programmed cell death pathway mediated by gasdermin proteins.
  • Gasdermin activation, often by inflammasomes, leads to cell membrane pore formation.
  • Dysregulated pyroptosis contributes to various inflammatory diseases.

Purpose of the Study:

  • To review the inflammatory consequences of pyroptosis.
  • To elucidate mechanisms of pyroptosis-induced tissue damage.
  • To discuss pyroptosis's role in disease pathogenesis.

Main Methods:

  • Literature review of pyroptosis mechanisms.
  • Analysis of gasdermin family activation pathways.
  • Examination of pyroptosis in disease models.

Main Results:

  • Gasdermin cleavage by proteases initiates pyroptosis.
  • Both inflammasome-dependent (GSDMD) and independent pathways exist for gasdermins.
  • Excessive pyroptosis triggers cytokine storms and organ damage.

Conclusions:

  • Pyroptosis is a critical immune response but can be detrimental when excessive.
  • Understanding pyroptosis mechanisms is key to treating inflammatory diseases.
  • Targeting pyroptosis may offer therapeutic strategies for sepsis, ARDS, and neurodegeneration.