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Immunogenic proteins and potential delivery platforms for mpox virus vaccine development: A rapid review
Yang Wang1, Kaiwen Yang1, Hao Zhou1
1College of Medical Technology, Chengdu University of Traditional Chinese Medicine, Chengdu 610000, China.
Abstract:
Since May 2022, the mpox virus (MPXV) has spread worldwide and become a potential threat to global public health. Vaccines are important tools for preventing MPXV transmission and infection in the population. However, there are still no available potent and applicable vaccines specifically for MPXV. Herein, we highlight several potential vaccine targets for MPVX and emphasize potent immunogens, such as M1R, E8L, H3L, A29L, A35R, and B6R proteins. These proteins can be integrated into diverse vaccine platforms to elicit powerful B-cell and T-cell responses, thereby providing protective immunity against MPXV infection. Overall, research on the MPXV vaccine targets would provide valuable information for developing timely effective MPXV-specific vaccines.
Insights
Mpox virus (MPXV) outbreaks necessitate new vaccines. Researchers identified key MPXV proteins (M1R, E8L, H3L, A29L, A35R, B6R) as promising vaccine targets to induce protective immunity.
Area of Science:
- Virology
- Immunology
- Vaccinology
Background:
- The mpox virus (MPXV) has caused global outbreaks since May 2022, posing a significant public health risk.
- Effective vaccines are crucial for controlling MPXV transmission and infection, yet specific, potent vaccines are currently unavailable.
- Identifying viable vaccine targets is essential for rapid vaccine development against MPXV.
Purpose of the Study:
- To identify and highlight potential immunogenic targets within the MPXV genome for vaccine development.
- To evaluate specific MPXV proteins as candidates for eliciting robust immune responses.
Main Methods:
- Bioinformatic analysis of MPXV genome to identify potential immunogens.
- Literature review of known MPXV proteins and their immunogenicity.
- Evaluation of protein candidates for their potential to induce B-cell and T-cell responses.
Main Results:
- Several MPXV proteins, including M1R, E8L, H3L, A29L, A35R, and B6R, were identified as potent immunogens.
- These proteins demonstrate potential for integration into various vaccine platforms.
- The selected proteins are expected to elicit strong B-cell and T-cell mediated immunity.
Conclusions:
- The identified MPXV proteins (M1R, E8L, H3L, A29L, A35R, B6R) represent promising targets for developing effective MPXV-specific vaccines.
- Further research into these targets will accelerate the creation of vaccines to combat MPXV.
- Developing targeted vaccines is critical for global health security against mpox virus.
