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Factors associated with respiratory morbidity in the first year of life
Samantha M Lessa1, Daniela C Tietzmann2, Sérgio L Amantéa1
1Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Departamento de Pediatria, Porto Alegre, RS, Brazil.
Insights
Maternal smoking and short breastfeeding duration increase infant respiratory illness risk in Brazil. Being born in the South also poses a higher risk for respiratory morbidity.
Area of Science:
- Pediatrics
- Public Health
- Epidemiology
Background:
- Respiratory morbidity is a significant health concern in infants.
- Socioeconomic and nutritional factors may influence respiratory health outcomes.
- Regional disparities in Brazil may impact infant health.
Purpose of the Study:
- To investigate the association between socioeconomic and nutritional factors with respiratory morbidity in the first year of life.
- To examine these associations across different regions of Brazil.
Main Methods:
- A nested case-control study was conducted in three Brazilian cities.
- 222 children were included, with cases defined as those with a history of asthma, bronchiolitis, or pneumonia.
- Bivariate and multivariate logistic regression analyses were used to assess risk factors.
Main Results:
- Maternal smoking (OR=2.12) and breastfeeding for less than six months (OR=2.05) were significantly associated with increased respiratory disease risk.
- Infants born in the Southern region of Brazil had a higher risk of respiratory morbidity.
- Ultra-processed food consumption did not show a significant association with respiratory disease.
Conclusions:
- Maternal smoking, insufficient breastfeeding, and birth in Southern Brazil are identified risk factors for infant respiratory morbidity.
- Ultra-processed food consumption, despite high prevalence, did not emerge as a significant risk factor in this study.
Objectives:
To investigate the association between socioeconomic and nutritional factors with respiratory morbidity in the first year of life in different regions of Brazil.
Methodology:
A nested case-control study within a randomized field trial was conducted in three capital cities (Porto Alegre, Manaus, and Salvador), representing different macro-regions of the country. Cases were defined as children with a reported previous diagnosis of asthma, bronchiolitis, or pneumonia. Corresponding controls were matched by age and sex in a 2:1 ratio, selected consecutively from the original cohort, resulting in a sample of 222 children. Bivariate analyses were performed to assess the association between sociodemographic and nutritional variables with respiratory morbidity outcomes, calculating odds ratios (OR) and their respective confidence intervals (95% CI). Values of p < 0.05 were considered significant. Potential confounding factors were adjusted through multivariate analysis (logistic regression).
Results:
Maternal smoking and breastfeeding for less than six months showed a significant association and increased risk of respiratory disease (OR=2.12 and 2.05, respectively). Children born in the Southern region of Brazil also demonstrated a higher association and risk of respiratory morbidity. The consumption of ultra-processed foods did not show a significant association or increased risk of respiratory disease.
Conclusions:
Maternal smoking, breastfeeding for less than six months, and being born in the Southern region of Brazil are risk factors for the development of respiratory morbidity in the first year of life. The consumption of ultra-processed foods does not appear to pose a risk, but it was prevalent in more than 80% of the population, limiting its discriminatory power of analysis.
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