The development of the pediatric stroke neuroimaging platform (PEDSNIP)
Trish Domi1, Amanda Robertson2, Wayne Lee3
1Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, Ontario, Canada.
Neuroimage. Clinical
|June 24, 2023
Summary
Pediatric Stroke Neuroimaging Platform (PEDSNIP) enhances childhood stroke research by pooling multisite neuroimaging data. This resource facilitates understanding of brain injury, repair, and outcomes, aiming for better treatments and improved quality of life.
Area of Science:
- Neuroscience
- Pediatric Neurology
- Medical Imaging
Background:
- Childhood stroke is a leading cause of death and disability.
- Understanding brain injury and repair mechanisms in pediatric stroke is limited.
- Existing neuroimaging studies are often small and single-centered.
Purpose of the Study:
- To establish a robust infrastructure for pediatric stroke neuroimaging research.
- To harmonize multisite data collection and analysis protocols.
- To create a large, searchable dataset for hypothesis-driven research.
Main Methods:
- Development of the Pediatric Stroke Neuroimaging Platform (PEDSNIP).
- Creation of a Clinical-MRI Data Repository and a Research-MRI dataset.
- Prospective data collection across eight North American centers with harmonized advanced MRI protocols.
Main Results:
- Established PEDSNIP, a centralized platform for pediatric stroke neuroimaging data.
- Built a large, collaborative dataset linking neuroimaging, clinical, genetic, and proteomic information.
- Enabled the largest worldwide pool of pediatric stroke data for research.
Conclusions:
- PEDSNIP provides essential infrastructure to advance pediatric stroke research.
- The platform facilitates the study of injury, repair, and outcomes in childhood stroke.
- This resource has the potential to accelerate discovery of mechanism-targeted treatments and improve patient outcomes.
