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Related Experiment Videos

Decrease in the autonomic innervation of human detrusor muscle in outflow obstruction.

J A Gosling, S A Gilpin, J S Dixon

    The Journal of Urology
    |August 1, 1986
    PubMed
    Summary

    Bladder outflow obstruction significantly reduces autonomic nerves in the detrusor muscle. This nerve loss contributes to urinary bladder dysfunction, highlighting the importance of timely treatment for obstruction.

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    Area of Science:

    • Urology
    • Neuroanatomy
    • Pathophysiology

    Background:

    • Bladder outflow obstruction (BOO) is a common condition affecting urinary bladder function.
    • The precise impact of BOO on the detrusor's autonomic innervation requires further elucidation.

    Purpose of the Study:

    • To quantitatively assess autonomic nerve density in the detrusor muscle of patients with BOO.
    • To compare nerve density between obstructed and unobstructed bladders.

    Main Methods:

    • Urodynamic confirmation of bladder outflow obstruction.
    • Quantitative analysis of autonomic nerve content in detrusor biopsy samples using light and electron microscopy.
    • Adjustments for muscle cell hypertrophy and increased connective tissue.

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    Main Results:

    • A statistically significant reduction in autonomic nerve supply to the detrusor muscle was observed in patients with BOO compared to controls.
    • Bladder outflow obstruction was associated with muscle cell hypertrophy and increased connective tissue.

    Conclusions:

    • Functional impairment of the urinary bladder in BOO is associated with a loss of autonomic innervation.
    • Prompt relief of bladder outflow obstruction is crucial to prevent or mitigate bladder dysfunction.