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[Evidence of iSGLT2 in the treatment of chronic kidney disease]

Alberto Calderón Montero1

  • 1Centro de Salud Doctor Pedro Laín Entralgo, Alcorcón, Madrid, España.

Semergen
|June 24, 2023
PubMed

Insights

Chronic kidney disease (CKD) is a growing global health concern. Sodium-glucose cotransporter type 2 inhibitors now represent a revolutionary, cornerstone treatment for cardiorenal protection in CKD patients.

Area of Science:

  • Nephrology
  • Cardiology
  • Pharmacology

Context:

  • Chronic kidney disease (CKD) prevalence and incidence are increasing globally, posing a significant future health burden.
  • CKD is a major contributor to cardiovascular morbidity and mortality, forming a critical cardiorenal axis with cardiovascular diseases.
  • Historically, renin-angiotensin system inhibitors were the primary disease-modifying treatments for CKD.

Purpose:

  • To highlight the recent advancements in pharmacological treatments for chronic kidney disease.
  • To emphasize the role of novel therapeutic agents in managing cardiorenal outcomes.

Summary:

  • The advent of sodium-glucose cotransporter type 2 (SGLT2) inhibitors has transformed CKD management.
  • SGLT2 inhibitors offer significant cardiovascular and renal protection.
  • These benefits extend to both diabetic and non-diabetic patients with CKD.

Impact:

  • SGLT2 inhibitors are now considered the cornerstone of current CKD management strategies.
  • This represents a paradigm shift in treating a leading chronic disease and its cardiovascular complications.

Keywords:
Cardiorenal axisChronic kidney diseaseEje cardiorrenalEnfermedad renal crónicaInhibidores del cotransportador sodio glucosa tipo2MortalidadMortalitySodium glucose co-transporter type2 inhibitors

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