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Paediatric Adhesive Small Bowel Obstruction is Associated with a Substantial Economic Burden and High Frequency of
Cecilia Arana Håkanson1, Fanny Fredriksson2, Helene Engstrand Lilja3
1Department of Women's and Children's Health, Karolinska Institutet, Tomtebodavägen 18a, 171 77, Solna, Sweden.
Insights
Neonatal surgery frequently causes adhesive small bowel obstruction (ASBO) in children, often requiring surgery and leading to complications and high costs. Further research is needed for effective paediatric ASBO management guidelines.
Area of Science:
- Pediatric Surgery
- Gastroenterology
- Surgical Complications
Background:
- Intra-abdominal adhesions are a common cause of adhesive small bowel obstruction (ASBO), with a higher incidence in pediatric surgery.
- Despite its prevalence, ASBO in children lacks clear management guidelines, and associated complications and economic burdens are not well-defined.
Purpose of the Study:
- To investigate the underlying diagnoses, treatments, complications, and healthcare costs associated with pediatric ASBO.
- To identify the primary drivers of ASBO in the pediatric population.
Main Methods:
- An observational retrospective study of children aged 0-15 years hospitalized for ASBO between 2000 and 2020.
- Data extraction from medical records, with complications classified using the Clavien-Dindo Classification.
- Kaplan-Meier estimates were used for time-to-ASBO analysis.
Main Results:
- 101 patients with 137 ASBO episodes were analyzed; 58.4% had initial surgery during the neonatal period.
- Necrotizing enterocolitis, duodenal obstruction, and primary ASBO were the most common index surgery diagnoses.
- Conservative treatment failed in 86.6% of patients, necessitating laparotomy; 52% experienced postoperative complications, with a median cost of $36,236 per ASBO episode.
Conclusions:
- Neonatal surgery is a primary cause of pediatric ASBO, frequently requiring surgical intervention.
- Paediatric ASBO is associated with a high rate of postoperative complications and substantial healthcare expenditures.
- Development of evidence-based management guidelines for pediatric ASBO is crucial.
Background:
Intra-abdominal adhesions can lead to adhesive small bowel obstruction (ASBO). The incidence of ASBO is higher in paediatric surgery than in adult surgery. However, ASBO related complications, economic burden and clear management guidelines in the treatment of ASBO are lacking. The aims of this study were to investigate underlying diagnoses, treatments, complications and costs in paediatric ASBO.
Method:
An observational retrospective study in children 0-15 years, hospitalised for ASBO during 2000-2020. Data were extracted from the medical records. Complications were classified based on Clavien Dindo Classification of Surgical Complications. Descriptive statistics were presented as median, continuous variables and categorical variables summarised with frequencies. Time to ASBO was presented as a Kaplan-Meier estimate.
Results:
In total, 101 patients with 137 episodes of ASBO were included whereof 58.4% underwent first (index) surgery during the neonatal period. Median follow-up was 11.3 (0.6-19) years and median time to the first ASBO was 3.76 months (95%CI 2.23-12.02). The most common diagnoses at index surgery were necrotising enterocolitis, duodenal obstruction and primary ASBO. In 86.6% of the patients, first ASBO did not resolve with conservative treatment and a laparotomy was needed. Postoperative complications were found in 52%. Median cost for one episode of acute ASBO was 36 236 USD (1629-236 159).
Conclusion:
Neonatal surgery was the dominating cause of ASBO and surgical intervention the most common treatment with a high frequency of postoperative complications and significant healthcare costs. Future studies are needed to develop safe management guidelines for the treatment of paediatric ASBO.
Levels Of Evidence:
III.
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