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Legionnaires' disease: one person's perspective.

J P Sanford

    Annals of Internal Medicine
    |April 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Legionella pneumophila causes Legionnaires' disease, a severe respiratory illness. Diagnosis is improving with new methods like ELISA, and erythromycin is an effective treatment.

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    Area of Science:

    • Infectious Diseases
    • Microbiology
    • Public Health

    Background:

    • The 1976 Philadelphia outbreak identified Legionella pneumophila as the cause of Legionnaires' disease.
    • The disease presents with diverse symptoms, including respiratory, neurological, and renal involvement.
    • Legionella pneumophila is an opportunistic pathogen found in water systems.

    Purpose of the Study:

    • To review the progress in understanding Legionnaires' disease since its identification.
    • To highlight diagnostic advancements and effective treatments.
    • To discuss the epidemiology and environmental sources of Legionella pneumophila.

    Main Methods:

    • Review of clinical features, epidemiology, and diagnostic methods for Legionnaires' disease.
    • Identification of causative agent Legionella pneumophila.

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  • Evaluation of diagnostic techniques including antibody titers, direct fluorescent antibody tests, and ELISA.

    • Main Results:

    • Legionnaires' disease involves multiple organ systems beyond the respiratory tract.
    • Erythromycin is an effective antimicrobial agent for treatment.
    • New diagnostic tools like direct fluorescent antibody and ELISA offer improved detection.

    Conclusions:

    • Significant progress has been made in identifying and understanding Legionnaires' disease.
    • Early diagnosis and treatment with erythromycin are crucial.
    • Environmental control and improved diagnostic methods are key to managing Legionella pneumophila infections.