Mechanosensory Feedback in Lamprey Swimming Models and Applications in the Field of Spinal Cord Regeneration

The central pattern generator (CPG) in anguilliform swimming has served as a model for examining the neural basis of locomotion. This system has been particularly valuable for the development of mathematical models. As our biological understanding of the neural basis of locomotion has expanded, so too have these models. Recently, there have been significant advancements in our understanding of the critical role that mechanosensory feedback plays in robust locomotion. This work has led to a push in the field of mathematical modeling to incorporate mechanosensory feedback into CPG models. In this perspective piece, we review advances in the development of these models and discuss how newer complex models can support biological investigation. We highlight lamprey spinal cord regeneration as an area that can both inform these models and benefit from them.