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SGLT2 Inhibitors in the Management of Chronic Kidney Disease: An Expert Consensus

Vivekanand Jha1, Alan Almeida2, Arpita R Choudhury3

  • 1Executive Director, The George Institute for Global Health, New Delhi, India; School of Public Health, Imperial College, London, UK; Prasanna School of Public Health, Manipal Academy of Higher Education, Manipal; Corresponding Author.

The Journal of the Association of Physicians of India
|June 25, 2023
PubMed

Insights

Sodium-glucose cotransporter-2 inhibitors (SGLT2i) show promise in slowing chronic kidney disease (CKD) progression and improving survival, even in patients with reduced estimated glomerular filtration rate (eGFR). Expert nephrologists discussed the role of SGLT2i in CKD management.

Area of Science:

  • Nephrology
  • Pharmacology

Background:

  • Chronic kidney disease (CKD) management requires improved therapies to slow progression and prevent complications.
  • The Dapagliflozin and Prevention of Adverse Outcomes in CKD (DAPA-CKD) trial revealed renoprotective effects of sodium-glucose cotransporter-2 inhibitors (SGLT2i).

Purpose of the Study:

  • To summarize expert nephrologists' views on the role of SGLT2i in CKD management.
  • To enhance understanding of SGLT2i applicability in CKD patients.

Main Methods:

  • A consensus meeting of Indian nephrology experts was held in September 2020.
  • Discussion focused on recent evidence regarding SGLT2i in CKD.

Main Results:

  • Dapagliflozin, an SGLT2 inhibitor, demonstrated renoprotective effects and improved survival in CKD patients, irrespective of diabetes status.
  • Benefits were observed even in patients with estimated glomerular filtration rate (eGFR) as low as 25 mL/min/1.73 m2 and those on optimal existing therapies.

Conclusions:

  • SGLT2 inhibitors represent a potential new therapeutic option for CKD management.
  • This expert consensus aims to guide nephrologists and physicians in utilizing SGLT2i for CKD patient care.

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