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Correlation between lipid-lowering therapy and cerebral microbleeds.

Miao-Ping Hong1, Wei-Fen Chen2, Jie-Hao Wu3

  • 1Department of Neurology, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.

Clinical Hemorheology and Microcirculation
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Summary

Statin use in ischemic cerebrovascular disease patients showed no link to the overall number of cerebral microbleeds (CMBs). However, statins were associated with lobar CMBs, with no significant difference between atorvastatin and rosuvastatin.

Keywords:
CMBsCerebral small vessel diseasesstatin

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Area of Science:

  • Neurology
  • Cardiovascular Research
  • Radiology

Background:

  • Cerebral microbleeds (CMBs) are common in patients with ischemic cerebrovascular disease (ICVD).
  • Statins are widely used for lipid-lowering treatment in ICVD patients.
  • The association between statin use and CMBs requires further investigation.

Purpose of the Study:

  • To examine the correlation between statin therapy and the presence, quantity, and location of CMBs in ICVD patients.
  • To compare atorvastatin and rosuvastatin regarding their effects on CMB occurrence.

Main Methods:

  • Retrospective analysis of 522 ICVD patients who underwent susceptibility-weighted imaging (SWI).
  • Data collected included statin use, medical history, clinical indicators, and imaging findings.
  • Patients were grouped based on statin use (atorvastatin, rosuvastatin) and CMB presence/characteristics.

Main Results:

  • Out of 522 patients, 40.6% had CMBs.
  • No significant correlation was found between prior statin use and the occurrence or number of CMBs (P<0.05).
  • A significant correlation existed between prior statin use and lobar CMBs (P<0.048), but not with other locations.
  • No significant difference in CMB occurrence was observed between atorvastatin and rosuvastatin users (P>0.05).

Conclusions:

  • Statin use in ICVD patients is not independently correlated with the overall occurrence or number of CMBs.
  • A correlation exists between prior statin use and the presence of lobar CMBs.
  • Atorvastatin and rosuvastatin showed no significant difference in CMB occurrence in this patient cohort.