Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

127
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
127
Psychoneuroimmunology: Cardiovascular Disease01:27

Psychoneuroimmunology: Cardiovascular Disease

54
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
54
The Blood-brain Barrier00:49

The Blood-brain Barrier

47.6K
Overview
47.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Solution-solid-solid mechanism: superionic conductors catalyze nanowire growth.

Nano letters·2013
Same author

Depending on the stage of hepatosteatosis, p53 causes apoptosis primarily through either DRAM-induced autophagy or BAX.

Liver international : official journal of the International Association for the Study of the Liver·2013
Same author

Low-voltage switching of crease patterns on hydrogel surfaces.

Advanced materials (Deerfield Beach, Fla.)·2013
Same author

Long non-coding RNAs and prostate cancer.

Journal of nanoscience and nanotechnology·2013
Same author

Self-assembled graphene quantum dots induced by cytochrome c: a novel biosensor for trypsin with remarkable fluorescence enhancement.

Nanoscale·2013
Same author

Relationship between glutathione S-transferase P1 (GSTP1), X-ray repair cross complementing group 1 (XRCC1) and 5,10-methylenetetrahydrofolate reductase (5,10-MTHFR) gene polymorphisms and response to chemotherapy in advanced gastric cancer.

Onkologie·2013

Related Experiment Video

Updated: Jul 25, 2025

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment
07:26

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment

Published on: July 18, 2017

11.9K

Elevated C-reactive protein mediates the liver-brain axis: a preliminary study.

Rongtao Jiang1, Jing Wu2, Matthew Rosenblatt3

  • 1Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT 06510, USA.

Ebiomedicine
|June 25, 2023
PubMed
Summary

Chronic liver disease and fibrosis are linked to cognitive decline and brain changes. Systemic inflammation may mediate these effects, suggesting early liver disease prevention could protect brain health.

Keywords:
Cognitive functioningFibrosis-4 scoreGrey matter atrophyHepatic fibrosisSystemic inflammation

More Related Videos

Sub-acute Cerebral Microhemorrhages Induced by Lipopolysaccharide Injection in Rats
06:39

Sub-acute Cerebral Microhemorrhages Induced by Lipopolysaccharide Injection in Rats

Published on: October 17, 2018

6.4K
Systems Analysis of the Neuroinflammatory and Hemodynamic Response to Traumatic Brain Injury
07:21

Systems Analysis of the Neuroinflammatory and Hemodynamic Response to Traumatic Brain Injury

Published on: May 27, 2022

3.2K

Related Experiment Videos

Last Updated: Jul 25, 2025

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment
07:26

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment

Published on: July 18, 2017

11.9K
Sub-acute Cerebral Microhemorrhages Induced by Lipopolysaccharide Injection in Rats
06:39

Sub-acute Cerebral Microhemorrhages Induced by Lipopolysaccharide Injection in Rats

Published on: October 17, 2018

6.4K
Systems Analysis of the Neuroinflammatory and Hemodynamic Response to Traumatic Brain Injury
07:21

Systems Analysis of the Neuroinflammatory and Hemodynamic Response to Traumatic Brain Injury

Published on: May 27, 2022

3.2K

Area of Science:

  • Neuroscience
  • Hepatology
  • Biomedical Science

Background:

  • Chronic liver diseases present a spectrum of hepatic fibrosis.
  • Existing research suggests a link between liver fibrosis and cognitive function.
  • Limited studies explore neurobiological factors and inflammation's role in the liver-brain axis.

Purpose of the Study:

  • To investigate the association between liver fibrosis and cognitive functioning.
  • To examine the relationship between liver fibrosis and regional grey matter volumes (GMVs).
  • To explore the mediating role of C-reactive protein (CRP) in the liver-brain axis.

Main Methods:

  • Utilized UK Biobank data for cross-sectional analysis.
  • Assessed liver fibrosis using the Fibrosis-4 score.
  • Analyzed cognitive performance, regional GMVs, and serum CRP levels, adjusting for covariates.

Main Results:

  • Liver fibrosis significantly correlated with impaired cognitive performance across multiple domains.
  • Significant associations were found between liver fibrosis and reduced GMVs in key brain regions like the hippocampus and thalamus.
  • Elevated CRP levels mediated the impact of liver fibrosis on cognitive function and GMVs.

Conclusions:

  • Established a strong link between liver fibrosis, cognitive impairment, and grey matter atrophy.
  • Highlighted systemic inflammation as a potential mediator on the liver-brain axis.
  • Emphasized early liver disease prevention to mitigate cognitive decline and brain volume loss.