Evaluation of Nonintubated Analgesia Practices in Critical Care Transport

Current analgesia recommendations in the prehospital setting are not specific to critical care transport. Variation exists in the recommended agent and dosing strategies. Furthermore, there is a paucity of literature evaluating benzodiazepine and opiate coadministration, which may place patients at risk for respiratory decompensation.

This was a retrospective chart review of nonintubated adult critical care transport patients between July 1, 2020, and July 1, 2022, who received fentanyl or ketamine during transport. The primary outcome was the proportion of patients oversedated. The secondary outcomes were characterization of analgesic medication use during transport, the percentage of patients coadministered benzodiazepines, naloxone administration, and escalation of respiratory intervention.

Three hundred seventy-six patients were administered fentanyl or ketamine during transport. Eleven patients were oversedated. Three hundred twenty-four patients received fentanyl monotherapy, and 52 received combination therapy. Patients who received benzodiazepines had higher odds of oversedation (odds ratio = 5.75; 95% confidence interval, 1.6-20.7). Two hundred thirty-six patients required an escalation in respiratory support, most commonly an increase from room air to nasal cannula. No patients had naloxone administered.

The rate of oversedation of nonintubated adult critical care transport patients receiving fentanyl or ketamine is low. Coadministration of benzodiazepines increases the risk of oversedation.