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Updated: Jul 25, 2025
07:24
A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy
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[Causes of Abnormal Hemoglobin Electrophoresis]
Xue-Li Pang1, Hong-Fei DU1, Yan Yang1
1Department of Clinical Laboratory, The First Affiliated Hospital of Chengdu Medical College, 2Chengdu Medical College, Chengdu 610500, Sichuan Province, China.
Zhongguo Shi Yan Xue Ye Xue Za Zhi
|June 25, 2023
Summary
Abnormal hemoglobin electrophoresis results can stem from various conditions, including thalassemia, iron deficiency anemia, and thyroid dysfunction. Comprehensive analysis of patient indicators is crucial for accurate diagnosis.
Area of Science:
- Hematology
- Clinical Biochemistry
- Medical Diagnostics
Context:
- Hemoglobin electrophoresis is a key diagnostic tool for identifying various blood disorders.
- Understanding the diverse causes of abnormal results is essential for effective clinical management.
- This study analyzed 5,696 patient results from a tertiary care hospital over three years.
Purpose:
- To investigate the spectrum of conditions leading to abnormal hemoglobin electrophoresis findings.
- To correlate abnormal electrophoresis patterns with specific diagnoses and clinical significance.
- To identify the prevalence of different causes among abnormal hemoglobin electrophoresis results.
Summary:
- Out of 5,696 patients, 8.53% exhibited abnormal hemoglobin electrophoresis.
- Key findings included elevated or decreased Hemoglobin A2 (HbA2), elevated Hemoglobin F (HbF), and abnormal hemoglobin bands.
- Thalassemia gene positivity was observed in 50.62% of abnormal cases, with β-thalassemia being most prevalent.
Impact:
- Identified thalassemia, iron deficiency anemia, macrocytosis, thyroid dysfunction, and hereditary persistence of fetal hemoglobin as significant causes.
- Highlights the importance of integrating electrophoresis results with clinical data for accurate diagnosis.
- Provides insights into the differential diagnosis of abnormal hemoglobin electrophoresis, aiding clinicians in patient management.
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